Data Science Analyst I - Psychiatric Genomics (Roussos Lab)

Mount Sinai Health System

New York, NY

New York, NY, US
New York, NY
30+ days ago
Data Science Analyst I - Psychiatric Genomics (Roussos Lab)

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

Roles amp; Responsibilities:

A position at the Pamela Sklar Division of Psychiatric Genomics (DPG) at Icahn School of Medicine at Mount Sinai is available for a Data Science Analyst 1 for joint projects of the Voloudakis and Roussos labs. The post will suit a self-motivated and talented individual who is interested in applying his/her skills at the interface of human disease and genetics.

The appointed Data Science Analyst 1 will be collaborating with an interdisciplinary team of clinicians, bioinformaticians, statistical geneticists, computational biologists and wet lab scientists. His/her projects will be involved in studies that aim to elucidate the genetic architecture and the genetic mechanisms through which risk variants increase vulnerability for neuropsychiatric diseases and affect treatment response. The distinguishing features of our research are the utilization of large-scale omics data in human brain tissue to (a) increase our understanding of disease process and (b) explore translational applications in the largest genotyped cohort with Electronic Health Records (Million Veteran Program). The successful candidate will be primarily responsible for: (1) computational analyses of whole-genome/exome sequencing datasets and genome-wide SNP array, with the aim to characterize different classes of sequence and genotyping variants; (2) modeling the genetic architecture from sequencing and genome-wide SNP data with aim to compare traits across molecular pathways and functional omics data derived from multiple tissues/cell types; and (3) computational analyses of whole-genome/exome sequencing datasets, with the aim to identify somatic variants in neuropsychiatric diseases.


  • Develop and maintain genetic, genomic, and biological databases to annotate and interpret human genome data.
  • Analyze whole genome/exome sequencing and genome-wide SNP array data.
  • Develop and implement algorithms, statistical methods and software to analyze large-scale human sequencing data and perform integrative functional analysis.
  • Publish and present novel research findings in academic journals and conferences.


  • PhD education in Statistical Genetics, Computational Biology, Population Genetics/Genomics, Computer Science, physics or related field.
  • 4+ years of experience in statistical genetics (can overlap with e.g. PhD).
  • Firm grounding in statistical methods for genome data analysis. An outstanding candidate will have experience in developing methods to explore heritability and/or integration with other omics data and/or prioritization (e.g. mendelian randomization)
  • Experience with biological datasets and next generation sequencing data.
  • Experience analyzing large-scale genetic datasets in complex human traits or disease and using main statistical packages for genetic data (e.g. GCTA and SNPtest).
  • Excellent programming skills in at least two of these languages on a Linux environment: Python, R, bash, Perl, Java, and C++. An outstanding candidate will have developed resource-efficient software and/or pipelines that work across different environments (e.g. air gapped systems with minimum dependencies, LSF clusters and cloud)
  • Track record of delivering complex scientific projects through high impact factor publications.
  • Excellent communication and organizational skills with ability to work to tight timelines, both independently and as part of a multi-disciplinary team.
  • An analytical mindset with problem-solving skills

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

  • Serving as the primary resource management representative of the Mount Sinai leadership teams, committees, etc., and acting as the primary executive leader interface between Mount Sinai and key executives from the health systemsrsquo; vendors and partners.
  • Engaging with relevant thought leaders and policy-makers at the federal and state levels, and representing the Health System as assigned.
  • Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.
  • Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.
  • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

We work hard to acquire and retain the best people, and to create a welcoming, nurturing work environment where you can develop professionally. We share the belief that all employees, regardless of job title or expertise, can make an impact on quality patient care.

Explore more about this opportunity and how you can help us write a new chapter in our history!

Who We Are

Over 42,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.

Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai Morningside (formerly Mount Sinai St. Lukersquo;s), and New York Eye and Ear Infirmary of Mount Sinai.

The Mount Sinai Health System (MSHS) provides equal employment opportunity to all its employees and applicants for employment without unlawful discrimination on the basis of their actual or perceived race, creed, color, religion, national origin, sex, gender, gender expression, gender identity, age, disability, marital or parental status, sexual orientation, veteran, immigration, citizenship, or other protected status.

EOE including Veterans and Disabled

Shift : Full-time
Primary Location: New York-New York

About the Company

Mount Sinai Health System