Director, IT Operations & Security

Senior Director, Opinion Leader Programming - Solid Biosciences

Charlestown, MA

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich's ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.

Patient-focused and founded by those directly impacted by Duchenne, Solid's mission is to improve the daily lives of patients living with devastating rare diseases.

We are seeking an experienced and technically hands-on Director of Information Technology to lead and scale enterprise IT operations within a growing clinical-stage biopharmaceutical organization. This role requires a strong blend of leadership, technical depth, cybersecurity expertise, and regulated industry experience in a GxP environment.

The Director of IT will be responsible for the overall architecture, security, operation, and strategic direction of the company's IT infrastructure, cloud services, enterprise platforms, cybersecurity program, and end-user computing environment. This individual will serve as both a strategic technology leader and senior technical escalation point, capable of actively architecting, troubleshooting, and supporting critical systems across cloud and on-premises environments.

The ideal candidate brings deep expertise across Microsoft enterprise technologies, cybersecurity, hybrid infrastructure, networking, endpoint management, compliance, disaster recovery, and validated systems commonly used within biotech and pharmaceutical environments.

This role reports to the VP of IT and will play a critical role in scaling IT operations, strengthening cybersecurity maturity, supporting regulated business systems, and building internal IT capabilities as the organization grows.

IT Infrastructure & Operations

• Lead the design, implementation, support, and continuous improvement of enterprise IT infrastructure across cloud and on-premises environments.
• Lead technical efforts for the deployment of AI across the enterprise
• Architect and maintain highly available, secure, and scalable systems supporting corporate, laboratory, and regulated business operations.
• Serve as the senior technical escalation point for complex infrastructure, systems, networking, and security issues.
• Develop and execute enterprise IT roadmaps aligned with business growth and operational objectives.
• Manage hybrid infrastructure environments including Microsoft Azure, AWS, Microsoft 365, virtualization platforms, Windows Server, Linux systems, storage, networking, and endpoint technologies.
• Oversee server, SAN, virtualization, backup, and datacenter infrastructure lifecycle management.
• Maintain operational excellence across enterprise systems including monitoring, patching, vulnerability remediation, performance tuning, and capacity planning.

Cybersecurity & Compliance

• Own and mature the company's cybersecurity program, policies, standards, and operational security posture.

• Partner with a managed security vendor to implement and operate SIEM, MDR/XDR, vulnerability management, endpoint detection and response, and incident response capabilities.

• Lead implementation of modern identity and access management solutions including Microsoft Entra ID, SSO, MFA, conditional access, and PAM/IAM frameworks.

• Ensure enterprise systems are secured following industry best practices and applicable regulatory requirements.

• Support compliance initiatives related to:

• 21 CFR Part 11

• SOX

• ISO 27001

• and all other relevant regulatory/security frameworks.

• Participate in audits, risk assessments, CAPAs, vendor assessments, and validation activities.

• Develop and maintain cybersecurity policies, disaster recovery plans, business continuity procedures, and incident response processes.

Microsoft Enterprise Technologies

• Lead enterprise administration and architecture of:

• Microsoft 365

• Azure

• Exchange Online

• Intune

• Autopilot

• Microsoft Purview

• Endpoint Management

• Data Loss Prevention (DLP)

• Conditional Access

• Defender ecosystem

• Entra ID.

• Standardize and secure endpoint management across corporate environments.

• Implement automation and operational efficiencies using PowerShell and infrastructure scripting.

Business Systems & Regulated Platforms

• Support and collaborate with stakeholders across regulated systems and business applications including:
• Support Computer System Validation (CSV) activities and validation lifecycle management for regulated environments.
• Ensure appropriate controls, documentation, and operational processes exist for regulated systems and electronic records/signatures compliance.

Networking & Infrastructure Security

• Manage enterprise networking infrastructure including:

• Cisco switching/routing

• wireless infrastructure

• VPN technologies

• segmentation

• firewall management.

• Administer and secure Palo Alto firewall environments and associated security services.

• Drive network security improvements aligned modern security architectures.

Leadership & Vendor Management

• Manage and mentor internal IT staff as the organization scales.
• Lead relationships with MSPs, security vendors, software providers, consultants, and infrastructure partners.
• Build operational processes, documentation standards, and scalable IT service delivery practices.
• Participate in budgeting, strategic planning, vendor negotiations, and technology evaluations.
• Collaborate cross-functionally with Quality, Clinical, Regulatory, Laboratory Operations, and executive leadership teams.

Qualifications

Required Qualifications

• Bachelor's degree in Information Technology, Computer Science, Engineering, or related field, or equivalent practical experience.
• CISSP or similar preferred
• 10+ years of progressive IT experience, including leadership responsibilities within regulated biotech, pharmaceutical, or life sciences environments.
• Strong hands-on technical expertise across:
• Microsoft 365 using Intune Autopilot Entra ID Purview Exchange Online

Windows Server Linux and virtualization platforms

• storage infrastructure, enterprise networking, endpoint management, cybersecurity operations.

• Understanding of GxP environments and 21 CFR Part 11 compliance requirements.

• Experience supporting validated systems and Computer System Validation (CSV) processes.

• Experience implementing business continuity and disaster recovery strategies.

• Advanced PowerShell scripting and automation experience.

• Experience administering Cisco networking and Palo Alto firewall technologies.

• Proven ability to operate effectively in both a strategic and technical capacity

• Experience building internal IT and security programs from the ground up.

Compensation

The base compensation range for this role is: $220,000 - 250,000

Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid's long term company performance.

Benefits and Solid Advantages

At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees' lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.

• Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
• 401(k) program participation with competitive company matched contributions
• Eligibility to participate in Solid's Employee Stock Purchase Plan
• Mobile phone subsidy for eligible employees
• Tuition Reimbursement
• Vision Coverage
• Life Insurance
• Voluntary Pet Insurance
• Employee Discount Program on Travel, Entertainment, and Services
• Employee Assistance Programs
• Daily Subsidized Lunch Delivery (onsite @ Hood Park)
• Free Onsite Full-Service Gym (onsite @ Hood Park)
• Employee Parking (onsite @ Hood Park)
• 12 Observed Holidays and a winter shut down
• 15-day PTO Policy and a 80-hour rollover YoY
• 40-hour Sick Policy
• 8 Hour Floating Holiday