Research Scientist/Engineer 2

University of Washington

Seattle, WA

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JOB DETAILS

SKILLS

Analysis Skills, Antibodies, Biochemistry, Biomolecules, Chemistry, Chromatographic Systems, Chromatography, Communication Skills, Compensation and Benefits, Data Analysis, Data Collection, Database Administration, Detail Oriented, Diversity, Identify Issues, Instrumentation, Inventory Management, Laboratory, Laboratory Analysis, Laboratory Equipment, Laboratory Management, Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry, Medicine, Nuclear Magnetic Resonance, Organic Chemistry, Organizational Skills, Problem Solving Skills, Quality Control, Regulatory Requirements, Research & Development (R&D), Scientific Research, Standard Operating Procedures (SOP), State Laws and Regulations, Sustainability, Team Building, Thin Layer Chromatography

LOCATION

Seattle, WA

POSTED

3 days ago

**Job Description** **The Institute for Protein Design has an outstanding opportunity for Research Scientist/Engineer 2 to join their team.** **About this Opportunity** As a member of the IPD Core R&D Labs, you will make important research contributions that accelerate progress in protein design. These teams develop new research methods, collect experimental data, and help interpret results. These activities are performed in collaboration with other scientists at the Institute for Protein Design or its collaborators; they are not available for external contract work. Peptide Core is seeking a RSE2 to join a Core focused on producing synthetic peptides to continuously support many projects in parallel at the IPD, such as biologic therapeutics, phosphopeptide synthesis and characterization, difunctional fluorescent peptides, and peptide materials. The Peptide Core also characterizes de novo proteins through intact protein mass spectrometry and returns valuable data analysis and quality control in a rapid fashion to the IPD. The successful candidate would work closely with IPD scientists to design, synthesize, troubleshoot, and analyze complex peptides and functional molecules. We are seeking a scientist with strong skills in critical thinking, troubleshooting, and a willingness to work in a fast-paced environment. A working knowledge of organic chemistry, bioconjugation, and protein biochemistry is required to effectively perform this role. **Key Responsibilities** (60%) Work with other Core R&D Lab members to accomplish research goals focused on peptide design and characterization. Specifically, the duties and responsibilities include: Produce a wide variety of synthetic peptides and "peptide-like" compounds utilizing solid-phase peptide synthesis (SPPS) with standard peptide chemistry techniques and using automated peptide synthesizers. Design and carry out multi-step syntheses utilizing organic chemistry techniques such as TLC, rotovap, flash chromatography, air-free techniques, and NMR. Optimize existing standard operating procedures for yield, efficiency, and throughput of peptides. Explore strategies to improve the throughput and quality of peptide synthesis pipelines. Document protocols run in the wet lab Review, analyze, and troubleshoot all experimental results (10%) Establishing and nurturing productive relationships with research colleagues, students, administrators, and others at IPD, including: Training IPD researchers on Core-specific workflow for peptide synthesis and purification. Work directly with Principal Investigators, postdoctoral fellows, graduate students, and laboratory staff in assisting with and conducting experiments. (15%) Perform routine data analysis of de novo proteins utilizing intact protein mass spectrometry Maintain and troubleshoot LC/MS instrumentation (Agilent) Develop and implement new methods as called for optimization of intact protein mixtures, antibodies Process and deconvolute results via software such as Agilent BioConfirm and PMI-Byos Work directly with researchers-postdoctoral fellows, graduate students, and laboratory staff-in communication of troubleshooting and results (5%) Maintain databases and inventories. This includes: Preparation and maintenance of standard laboratory stocks and reagents necessary to research workflow Maintain inventory for all chemicals, supplies, reagents, and biological samples Maintain and troubleshoot laboratory equipment, including prep-scale HPLCs (Agilent), peptide synthesizers (CEM, Gyros), flash chromatography system (Biotage), and lyophilizers (Labcon) Work with Laboratory Manager to assist with laboratory-wide EH&S compliance (5%) Assist with managing undergraduate research assistants. (5%) Present scientific data, attend meetings and team building events. **Required Qualifications** "To be considered for this opportunity your application must demonstrate you meet both the minimum qualifications and additional qualifications listed below. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration." **Minimum Requirements** Applicants who do not meet these qualifications WILL NOT be forwarded to the Hiring Department. Bachelor's Degree in Biochemistry, Chemistry or related field and 2 years of relevant experience in modern peptide synthesis techniques, purification and analysis. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration. **Additional requirements:** Strong communication and organization skills and great attention to detail A willingness to acquire new skills and learn on the job. Proficient in modern peptide synthesis techniques, purification and analysis **Desire:** At least three years of full-time laboratory experience Proficient with peptide chemistry and/or synthetic chemistry and/or medicinal chemistry Experience with lab instrument use and upkeep of: peptide synthesizers (CEM, Gyros), lyophilizers (SP, Labcon), rotovaps (Buchi), LC/MS (Agilent), HPLCs (Agilent) **Field of Research:** Located at the University of Washington in Seattle, the Institute for Protein Design is a unique interdisciplinary environment where world-class researchers create new biomolecules. Our mission is to create proteins that solve modern challenges in medicine, technology, and sustainability. Joining our team means becoming part of one of the largest and most innovative public universities in the world. Your work here will support scientific inquiry and help ensure that laboratory breakthroughs lead to positive impact. **Compensation, Benefits and Position Details** **Pay Range Minimum:** $69,600.00 annual **Pay Range Maximum:** $96,000.00 annual **Other Compensation:** - **Benefits:** For information about benefits for this position, visit https://www.washington.edu/jobs/benefits-for-uw-staff/ **Shift:** First Shift (United States of America) **Temporary or Regular?** This is a regular position **FTE (Full-Time Equivalent):** 100.00% **Union/Bargaining Unit:** UAW Research **About the UW** Working at the University of Washington provides a unique opportunity to change lives - on our campuses, in our state and around the world. UW employees bring their boundless energy, creative problem-solving skills and dedication to building stronger minds and a healthier world. In return, they enjoy outstanding benefits, opportunities for professional growth and the chance to work in an environment known for its diversity, intellectual excitement, artistic pursuits and natural beauty. **Our Commitment** The University of Washington is committed to fostering an inclusive, respectful and welcoming community for all. As an equal opportunity employer, the University considers applicants for employment without regard to race, color, creed, religion, national origin, citizenship, sex, pregnancy, age, marital status, sexual orientation, gender identity or expression, genetic information, disability, or veteran status consistent with UW Executive Order No. 81 (https://policy.uw.edu/directory/po/executive-orders/eo-81-prohibiting-discrimination-harassment-and-sexual-misconduct/) . To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or dso@uw.edu . Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law (https://app.leg.wa.gov/RCW/default.aspx?cite=28B.112.080) . University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to, among other things, race, religion, color, national origin, sexual orientation, gender identity, sex, age, protected veteran or disabled status, or genetic information.

About the Company

University of Washington

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