4D Molecular Therapeutics Jobs in the United States
4D Molecular Therapeutics
Emeryville, CA
Reporting to the Manager, Materials Management, this role is expected to work closely within the Supply Chain team, as well as cross-functional groups such as Facilities, Quality, Process Development, Quality Control, and Manufacturing for the successful execution and oversight of all raw material testing and release, as well as vendor providing testing services. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products.
4D Molecular Therapeutics
Emeryville, CA
We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. These individuals will bring exceptional clinical expertise and work closely with designated thought leaders to foster advocacy for nAMD treatment and the transformative potential of gene therapy, specifically 4D-150.
Acrivon Therapeutics
Watertown, MA
The company reported positive clinical data for ovarian and endometrial cancers in April 2024, and in September 2024 it reported additional positive clinical data for endometrial cancer, including a confirmed overall response rate of 62.5% (95% CI, 30.4 - 86.5) and further validation of its prospective OncoSignature selection of patients predicted sensitive to ACR-368 by showing segregation of responders in OncoSignature-positive versus OncoSignature-negative patients (p = 0.009). Acrivon’s ACR-368 OncoSignature test, which has not yet obtained regulatory approval, has been extensively evaluated in preclinical studies, including in two separate, blinded, prospectively-designed studies on pretreatment tumor biopsies collected from past third-party Phase 2 trials in patients with ovarian cancer treated with ACR-368.
Dyne Therapeutics
Waltham, MA
He/she will be responsible for or contribute to statistical activities including: designing innovative clinical trials, authoring statistical sections of protocols, preparing statistical analysis plans, ensuring quality in implementation of statistical analysis, interpreting and communicating the results of statistical analysis of clinical trial data in support of regulatory submissions as well as manuscripts. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD).
Dyne Therapeutics
Waltham, MA
Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). The Associate Director CMC, Biologics is responsible for supporting our internal CMC capabilities (antibody, new fusion proteins process & development) and for the management of external new fusion protein CDMO under cGMP.
Dyne Therapeutics
Waltham, MA
Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). The Associate Director, Clinical Business Operations works closely with cross functional teams to ensure a fit-for-purpose outsourcing strategy and budget management is achieved for each trial.
Dyne Therapeutics
Waltham, MA
Pro-actively engage with program/project teams and functional leaders to manage budgets, challenge assumptions and estimates, identify areas for improvement and/or cost savings, and ensure consistency between departmental financial plans, corporate goals, and program/project timelines. In this fast-paced and high-exposure role, this role interacts with senior leaders and finance team members throughout the organization to meet goals and objectives including partnering with the Clinical leadership teams, functional heads, and program/project teams to guide the future growth of Dyne.
Dyne Therapeutics
Waltham, MA
This position is responsible for initiating and leading clinical trials across all phases, including overseeing CROs and vendors and working cross-functionally on clinical operations strategy and related initiatives including aligning operational execution activities with agreed upon project priorities, timing, budget, and quality requirements. Minimum of 8 years of clinical trial management experience in conducting Phase I-III global clinical trials, preferably with both a sponsor company and CRO managing outsourced clinical trials within quality, timeline and budget expectations.
Dyne Therapeutics
Waltham, MA
Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). The Associate Director, Oligonucleotide CMC and External Manufacturing is responsible for building our internal CMC capability and for the management of external specialist Oligonucleotide CDMOs under cGMP.