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Principal Scientist - Computational Biology

Amgen

Thousand Oaks, CA

Basic Qualifications:Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of scientific/biopharma industry experienceOrMaster’s degree and 6 years of scientific/biopharma industry experienceOrBachelor’s degree and 8 years of scientific/biopharma industry experiencePreferred Qualifications:PhD in Bioinformatics, Mathematics, Statistics, Computer Science, Computational Biology, or Data Science, with a minor or robust background in BiologyA working knowledge of bioinformatics, applied mathematics, data science to analyze multi-modal, multi-dimensional and large-scale biological data sets such as those from next-generation sequencing DNASeq, RNASeq and proteomics assaysA working knowledge of platforms and readouts utilized for the assessment of clinical biomarkers including flow cytometry, IHC, NGS, immunoassays, imaging, MRD, transcriptional profiling, methylation, and single-cell assaysA good understanding and practical skill of statistics and their use in data analysis for clinical settingsA working knowledge and experience of Machine Learning and AI technologies-experience of applying ML/AI in clinical trial setting is requiredAbility to translate biological and medical questions into analytical models providing actionable resultsProgramming experience in R& PythonExperience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers and in explorations of mechanisms of action or resistanceFamiliarity with assay development and qualification requirements for clinical trial supportAbility to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research communityA strong scientific background with training in genetics and a proven track record of productivityStrong written and oral communication skills, self-motivation, independence, and leadershipWhat you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. Develop translational informatics analysis methods to enable the analysis of NGS data/Epigenomics assays/single-cell assays from clinical trialsDevelop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics and epigenomics domainsWork with biologists, especially in Heme-oncology, to leverage information on targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics and other high content databases.

Today
Principal Scientist - Computational Biology

Amgen

South San Francisco, CA

The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, ML algorithms & data science, statistical modeling, handling clinical data sets, and a background in biology and computational sciences. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

10 days ago
Principal Scientist Immunogenicity Bioanalytical

Amgen

Thousand Oaks, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models, including remote and hybrid work arrangements, where possibleApply nowfor a career that defies imaginationObjects in your future are closer than they appear. Previous experience working in a matrixed environment to implement immunogenicity assay development, validation, and sample analysisProject management skills to meet critical timelines associated with various activities necessary to support nonclinical and clinical studies.

Today
Scientist - Functional Genomics

Amgen

South San Francisco, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. In this vital role you will join an enthusiastic, fast-paced team utilizing cutting edge functional genomics and cellular profiling technologies to advance discovery and drug development across Amgens therapeutic areas.

21 days ago
Scientist Cell-Based Assay Development & Execution

Amgen

Thousand Oaks, CA

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. The development and optimization of novel cell-based assays ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets.

17 days ago
Scientist Oncology Research

Amgen

Thousand Oaks, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. The Department of Oncology Research at Amgen, Thousand Oaks is seeking a highly motivated Scientist to contribute to the discovery and validation of novel oncology targets with the goal of supporting the development of Amgens next generation of innovative small-molecule therapeutics.

Today
Principal Scientist - Cardiometabolic Disorders

Amgen

Thousand Oaks, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models, including remote and hybrid work arrangements, where possibleApply nowfor a career that defies imaginationObjects in your future are closer than they appear. Conceptualizing and proposing therapeutic targets for the treatment of cardiometabolic diseaseDesigning and performing in vitro and cell-based experimentsIndependently performing data analysis and interpreting resultsCommunicating scientific results through written and oral presentationsCollaborating with teams from other functions in the company to advance our programsDocumenting work through written protocols, electronic laboratory notebooks and study reports.

Today
Scientist - Translational Immunology

Amgen

South San Francisco, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.

8 days ago
Senior Scientist

Amgen

Thousand Oaks, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. In this vital role you will become part of a global multidisciplinary group focusing on process and product impact including material attributes, non-conformance investigations and characterization of polymers used in primary drug delivery systems, biological manufacturing process and how they impact both the process performance and product quality.

17 days ago
Senior Scientist -- Synthetics Separations

Amgen

Thousand Oaks, CA

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Today
Scientist Cell Line and Bioassay Development

Amgen

South San Francisco, CA

Expertise in the development and implementation of target engagement (TE), activity, functional, and phenotypic, and protein-protein interaction (PPI) assays to assess therapeutic agents, including thermal shift assay (TSA), probe displacement, second messenger, ion flux, reporter, protein stability, PPI (NanoBiT, NanoBRET, etc.), immunoassays, gene activation, and cellular imaging. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

21 days ago
Sr. Scientist, BioAnalytical Deveplopment (Bioassay) - Contract

TalentBurst, Inc.

$85 - $88 Per hour

San Francisco, CA

Must have in-depth knowledge and hands-on experience in plate-based and cell-based assay development, execution and troubleshooting, as well as expert knowledge of methods and immunoassay technologies, such as ELISA (direct and indirect sandwich formats), Luminescence, Colorimetric, Electrochemiluminescence (MSD), etc. to support animal and clinical studies. The successful candidate must be proficient in biological assay development (ELISA and cell-based) and be proficient in Quality Control execution and systems, stability study programs, method development/qualification/validation, and end to end CMC regulatory drug approval process for biologic drug substances and drug products.

5 days ago
Sr. Scientist II, Monoclonal Antibodies - Contract

TalentBurst, Inc.

$73 - $75 Per hour

San Francisco, CA

This position will work on the process development of monoclonal antibodies to be used for clinical study involving complex problems in which analysis of situations or data requires an in-depth evaluation of various factors and contributes to and supports the company’s research and development efforts to create high value therapeutics to address unmet medical needs. Exercises judgment within broadly defined practices and policies in selecting, and may recommend new methods, techniques and evaluation criteria for obtaining results throughout antibody production processes.

5 days ago
Senior Vendor Laboratory Manager - Contract

TalentBurst, Inc.

$71 - $71.15 Per hour

San Rafael, CA

Hybrid - Open to Remote for Ideal Candidate: Clinical Laboratory & Biospecimen Management (CLBM) is a group within Strategic Research and Development Operations (SRDO) that provides effective and efficient vendor oversight (operational, contractual, and financial) for Central and Specialty Laboratories involved in all stages of clinical trials. Relevant professional experience working in the pharmaceutical/biotechnology industry, clinical research setting or clinical/diagnostic/central or specialty laboratory which includes specimen management, biomarker operations, vendor management, translational sciences operations, clinical operations.

5 days ago
Bioanalytical Scientist I

AbbVie

East Irvine, CA

The Bioanalytical Scientist I, as part of Local Delivery Translational Sciences (LDTS) at the Irvine, California site at AbbVie will develop and perform non-regulated, non-clinical quantitative bioanalysis assays to quantify large molecule therapeutics using ligand binding assay for non-clinical pharmacokinetic, pharmacodynamic and safety studies to support drug discovery and development efforts. As a member of a small team, and under the mentorship of a supervisor, this individual will develop and perform quantitative non-regulated large molecule bioanalysis studies for in vitro and in vivo studies, document experiments, prepare formal reports, and present results to project teams.

3 days ago
Senior Biological Research Scientist I

AbbVie

East Irvine, CA

You willparticipate in a team of scientists to lead various activities, including target identification/validation and drug discovery using in vitro, in vivo, or omics methodologies to evaluate pharmacology in collaboration with internal and external stakeholders/experts. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.

21 days ago
Scientist I/II, Cell-Molecular biology, BGM

AbbVie

San Diego, MA

The successful candidate will be part of an innovative and fast-paced team working with cross-disciplinary groups both internally and externally to develop biochemical and cellular functional assays with a primary focus on metabolic diseases and biology of aging. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.

Today
Scientist, Molecular Core

AbbVie

San Diego, MA

As an integral part of the group, the ideal candidate will: Execute molecular biology workflows including Next-Generation Sequencing (NGS) to capture antibody sequences from hybridoma, single B cell, immune repertoires and in vitro sources enabling discovery of antibodies as well as novel therapeutic formats. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.

17 days ago