["Associate Director, Study Toxicologist","Associate Director, Study Toxicologist"]

About Madrigal Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction‑associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our team is committed to the shared purpose of leading the fight against MASH. Our medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑ agonist designed to target key underlying causes of MASH and is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3).Associate Director, Study Toxicologist – Overview This role focuses on the execution and scientific oversight of outsourced nonclinical studies supporting regulatory‑stage development programs. The Associate Director will partner closely with Nonclinical Development program leads to ensure studies support regulatory submissions and clinical development. The position is part of the Nonclinical Development team within Research, supporting Madrigal's growing MASH portfolio and providing opportunities over time to contribute more broadly to nonclinical development strategy.Key Responsibilities Study Design & Oversight – support the design and execution of nonclinical studies, including toxicology, PK, ADME, and bioanalytical studies; provide scientific oversight of outsourced studies, including protocol input, study monitoring, data review, and final report review.CRO & Study Management – coordinate study placement and management at CROs, including vendor interaction, study startup, and timeline tracking; monitor study conduct at external vendors to ensure quality and alignment with program timelines and objectives.Data Review & Collaboration – review and interpret study data and reports for accuracy, completeness, and scientific rigor; partner closely with Nonclinical Development program leads and cross‑functional teams to support integrated development plans and contribute scientific input to nonclinical development strategy; maintain clear communication with internal stakeholders and external partners throughout study execution.Qualifications PhD (or equivalent) in Toxicology, Pharmacology, DMPK, or a related scientific discipline.Relevant pharmaceutical or biotechnology industry experience supporting nonclinical development programs and 10+ years of relevant experience.Experience managing outsourced nonclinical studies with CROs, including protocol and report review.Strong attention to detail and ability to manage multiple studies simultaneously.Excellent written and verbal communication skills.Preferred: Experience with small molecule and/or siRNA programs.Preferred: Experience supporting late‑stage nonclinical studies, including reproductive and developmental toxicology (DART) and carcinogenicity studies.Benefits & Compensation Base salary $178,000 – $218,000 per year. All full‑time employees receive equity and a total rewards strategy based on a biotech industry peer group comparator, which includes base pay, bonus and equity. Full‑time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, 401(k) offerings (traditional, Roth and employer match) in accordance with applicable plans. Additional voluntary benefits include supplemental life insurance, legal services, and mental health benefits through our Employee Assistance Program. The company also provides other benefits in accordance with applicable federal, state, and local laws.EEO Statement Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.#J-18808-Ljbffr