["Senior Principal EA Applied AI Agentic Architecture","Senior Principal EA Applied AI Agentic Architecture"]

Senior Principal EA Applied AI Agentic Architecture

Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines. Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?

Entity: Corporate Services

Department: Enterprise Technology Architecture and Strategy

Location: Hybrid, 3535 Market St, Philadelphia, PA 19104

Summary: Principal Enterprise Architect – Applied AI & Agentic Architecture is the senior individual contributor role responsible for the solution and workflow-level architecture of applied AI, generative AI (GenAI), and agentic systems across the enterprise. This role serves as the authoritative enterprise architecture voice for how AI and GenAI capabilities are designed, integrated, governed, and consumed within clinical, operational, administrative, and digital environments. The Senior Principal defines and maintains enterprise standards, reference architectures, integration patterns, and responsible AI frameworks that enable the safe, compliant, and scalable deployment of AI use cases across the health system. This role operates at the intersection of clinical care, enterprise IT, and emerging AI technology, ensuring that AI investments are architecturally sound, clinically safe, ethically governed, and aligned to measurable organizational outcomes.

Responsibilities:

• Defines and owns enterprise reference architectures and design standards for applied AI, GenAI, and Agentic AI systems deployed into clinical, research, operational and administrative workflows.
• Architect Agentic AI and multi-agent system (MAS) patterns appropriate for enterprise and regulated clinical use, including agent orchestration, human-in-the-loop controls, and safety boundaries.
• Owns applied GenAI integration architecture including retrieval-augmented generation (RAG), prompt governance frameworks, LLM orchestration patterns, and API consumption standards across enterprise AI platforms.
• Establishes and maintains responsible AI guardrails, clinical AI safety frameworks, and applied AI risk controls, ensuring alignment with patient safety obligations and regulatory requirements.
• Represent in governance of AI use-case portfolio from an architecture perspective, including use-case value-cost-risk analysis, clinical applicability assessment, and architecture review for AI solutions entering production.
• Leads AI architecture scenario planning to anticipate regulatory, clinical safety, and technology risks, and embeds adaptive guardrails into enterprise AI architecture standards and governance frameworks.
• Applies human centered design and design thinking principles to AI architecture, ensuring solutions are aligned to end user needs, workflow integration, and the patient and clinician experience.
• Partners with clinical informatics, digital health, data & analytics and operational leaders to translate AI investments into architecturally sound, measurable enterprise outcomes.
• Develops and enforces enterprise AI consumption standards and integration patterns for EHR systems, clinical applications, operational platforms, and enterprise data services.
• Collaborates with Information Security, Privacy, Legal, Compliance, and Risk Management to ensure AI use cases meet HIPAA, patient safety, and applicable regulatory and audit requirements.
• Provides architecture advisory and review for AI-related vendor evaluations, procurement decisions, and enterprise product selections at the solution and workflow layer.
• Represents the applied AI architecture domain in enterprise architecture review boards, AI governance committees, and relevant executive steering bodies.
• Publishes and maintains AI architecture decision records, reference architectures, design patterns, and governance standards accessible to delivery teams and enterprise stakeholders.
• Monitors emerging AI, GenAI, and agentic AI trends; assesses implications for enterprise architecture standards, governance frameworks, and clinical safety posture.
• Serves as a senior architectural thought leader and trusted advisor to executive, clinical, and operational stakeholders on applied AI architecture matters.
• Performs duties in accordance with Penn Medicine and entity values, policies, and procedures.
• Other duties as assigned to support the unit, department, entity, and health system organization.

Credentials:

• Certified Machine Learning, Professional ML Engineer, AI Governance, or equivalent AI certification is preferred.

Education or Equivalent Experience:

• Bachelor's Degree is required.
• 10+ years Information Technology (IT) experience, with 7+ years Enterprise Architecture is required.
• 3+ years AI and Agentic AI Architecture is required.

We believe that the best care for our patients starts with the best care for our employees. Our employee benefits programs help our employees get healthy and stay healthy. We offer a comprehensive compensation and benefits program that includes one of the finest prepaid tuition assistance programs in the region. Penn Medicine employees are actively engaged and committed to our mission. Together we will continue to make medical advances that help people live longer, healthier lives. Live Your Life's Work

We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.