Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.
The Position
At Sequencing, you'll build and operate the evaluation and validation infrastructure that keeps our AI systems correct, reliable, and regression-protected. This is an execution-focused role: you'll design, implement, and maintain the benchmarking systems that continuously test AI outputs against curated genomic datasets, partnering closely with the AI Bioinformatics Engineering Lead to turn interpretation standards into measurable, operational systems. You are detail-oriented, have a systems-thinking mindset and you notice the one VCF out of ten thousand that doesn't look right
The Opportunity
- Build and run automated evaluation pipelines for AI outputs end-to-end.
- Expand regression datasets that cover variant normalization, transcript ambiguity, and disease-level mapping.
- Execute large-scale validation runs across curated VCF datasets, track performance over time, and surface accuracy regressions the moment they appear.
- Grow a structured question bank using and related datasets, encoding the edge cases that matter most.
- Ship automated regression tests for every AI release and build dashboards that make variant-level and case-level accuracy visible to the whole team.
- Partner with engineering to wire validation directly into CI/CD, and diagnose and document failure modes as they emerge.
Who you are
- Degree in Bioinformatics, Computational Biology, Genetics, or a related field.
- Deep, hands-on experience with VCFs and real-world genomic datasets.
- Fluency with ClinVar, dbSNP, HGVS standards, and transcript mapping.
- A track record building evaluation frameworks or testing pipelines, Langfuse or similar.
- Experience evaluating LLM-based systems and standing up automated QA at scale.
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Benefits Overview
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
Join Sequencing
- Redefine how people understand themselves through their DNA
- Build category-defining products alongside scientists, engineers, and innovators
- Contribute to technology that will improve and extend millions of lives
- Shape one of the most important emerging categories in AI and healthcare
Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting joinus@sequencing.com.
Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process.
All legitimate Sequencing roles are posted on our official careers page and require you to apply through our company application portal. If a role claiming to be with Sequencing asks you to apply or communicate outside of those channels, it is not an authentic opportunity with our team. During our hiring process, we or our recruitment partners will never ask you to send money, purchase equipment, or share bank, credit card, or Social Security information before a verified offer. We also will not make same day offers without interviews or ask you to communicate only through informal messaging apps. If you believe someone is misusing our name in a fake posting, please report it to the job board or verify the posting by contacting careers@sequencing.com.