Associate Research Scientist

Associate Research Scientist

Pay Rate: $42.16/hr.

Duration: 12 months

Location: Alameda, California

Shift: 8am-5pm PST with some flexibility

Job Description -

Top Skills:

1. HTS Assay Dvelopment & Screening (1536/384)
2. Biophysical Assays (SPR Preferred)
3. Experience with technologies such as: HTRF, AlphaLISA, MSD, ELISA, Fluorescence Polarization (FP), Luminescence-based assays
4. Laboratory Automation & Automated Screening Workflows

Strong Plus: Cellular assay experience

SUMMARY/JOB PURPOSE:

The candidate is responsible for conceptualization, development, optimization and execution of biophysical and biochemical assays to support hit identification and validation efforts in early-stage small molecule drug discovery projects. This scientist is also responsible for the development of automated High-Throughput Screening (HTS) biochemical (1536-well plate) and/or biophysical assays to profile compound mechanism of action (96-and 384-well plate formats) to advance research programs from discovery to development candidate nomination.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Independently develop, optimize and execute small molecule compound profiling and HTS biochemical and biophysical assays
• Consistently contribute to the design, planning, and execution of HTS campaigns and mechanism of action (MoA) studies
• Independently nominates, evaluates, and implements new technologies, protocols, and workflows to support projects from hit finding, hit validation, to lead optimization stages, as well as MoA studies
• Collaborates with internal groups and departments to discuss and resolve project and/or department needs

o Presents data and reports on project status to department head/manager and at discovery project and research meetings