The role: BigHat Biosciences is seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to BigHat’s antibody discovery and engineering efforts and help generate high-quality data to improve BigHat’s machine learning models using display technologies, working closely with senior scientists and cross-functional teams.
*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models.
Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties.
Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
Analyze selection results and contribute to discussions on next steps and future experimental design.
Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
Present experimental plans and results during regular meetings with manager and science teams.
Maintain thorough records using LIMS and electronic notebooks.
Skills Knowledge and Expertise
BS or MS in Biochemistry, Molecular Biology, Bioengineering, or a related field.
4+ years of hands-on laboratory experience (academic or industry); relevant internship or research experience welcome.
Familiarity with general molecular biology techniques (PCR, molecular cloning, gel electrophoresis).
Exposure to antibody biology, display technologies (phage or yeast), and protein expression.
Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records.
Effective time management and clear written and verbal communication skills.
Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms.
Total Rewards
The salary estimated for this position is $120,000 - $135,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
Dental, and vision coverage through Guardian
Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
401(k) with company match
DTO, two weeks of company-wide shutdown, and 12 company holidays
Paid parental leave
Numbers & Facts
Location
San Mateo, California
Skills
Analysis Skillsunmatched
Antibodiesunmatched
Assaysunmatched
Automationunmatched
Biochemistryunmatched
Bioengineeringunmatched
Biologyunmatched
Cloningunmatched
Communication Skillsunmatched
Compensation and Benefitsunmatched
Constructionunmatched
Cross-Functionalunmatched
Data Modelingunmatched
Data Qualityunmatched
Data Scienceunmatched
Experiment Designunmatched
Identify Issuesunmatched
Laboratory Information Management System (LIMS)unmatched
Machine Learningunmatched
Molecular Biologyunmatched
Polymerase Chain Reaction (PCR)unmatched
Presentation/Verbal Skillsunmatched
Quality Controlunmatched
Record Keepingunmatched
Research & Development (R&D)unmatched
Startupunmatched
Team Playerunmatched
Time Managementunmatched
Writing Skillsunmatched
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