Associate Scientist/Senior Associate Scientist, In Vivo Pharmacology - Study Coordinator

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

We are seeking an experienced and highly organized In Vivo Study Coordinator to own the end-to-end planning, coordination, and execution of our preclinical in vivo pharmacology programs. This is a senior, hands-on role at the intersection of scientific rigor and operational excellence - you will be the single point of accountability for study lifecycle management across multiple parallel programs, from initial study design through execution, collection, and delivery.

The ideal candidate brings deep in vivo pharmacology expertise, strong cross-functional coordination instincts, and the ability to operate independently in a fast-moving, early-stage environment. You are as comfortable building a detailed study timeline as you are troubleshooting a dosing day in real time - and you know when to push back on unrealistic timelines and when to find creative solutions.

Key Responsibilities

• Work closely with pharmacology team members to oversee and execute assays assessing the pharmacological activity, biodistribution, and efficacy of test articles in research and preclinical studies, supporting development of therapies across the pipeline.
• Manage tissue analysis and oversee the transfer and storage of samples from rodent and large animal studies performed at external contract vivarium facilities.
• Perform test article dosing via various administration routes, including systemic administration (I.V., I.P.).
• Perform rodent perfusion and tissue collection.
• Independently analyze and interpret data, with careful documentation of experiments and presentation of results within the company.
• Perform various molecular and biochemical assays on tissue samples from preclinical studies across a range of drug development programs, including quantitative and qualitative target analysis.

Required Qualifications

• Bachelor''s or Master''s degree in Biology, Pharmacology, Biomedical Science, or related field
• 5+ years of hands-on in vivo pharmacology experience in a biotech, pharma, or CRO environment
• Demonstrated experience as a study director, study coordinator, or study lead - owning studies end-to-end with accountability for timelines and deliverables
• Deep proficiency with in vivo techniques: IV, SC, IP, and PO dosing; submandibular and cardiac bleeds; necropsy; tissue collection and processing across a broad panel
• Experience coordinating multiple concurrent studies across different programs and timelines
• Strong organizational skills and attention to detail - you do not let things slip
• Excellent cross-functional communication - comfortable working with scientists, RAs, vivarium staff, and leadership simultaneously
• Self-motivated and capable of operating independently with minimal supervision
• A genuine passion for science and for building something impactful

Preferred Qualifications

• Experience with humanized or disease mouse models
• Familiarity with NHP study coordination and CRO management
• Experience with downstream bioanalytical assays - ELISA, MSD, qPCR, western blot, flow cytometry, IHC, IF
• Familiarity with histology, tissue sectioning, and confocal imaging workflows
• Experience with Benchling or similar LIMS platforms
• Exposure to protein therapeutics and other modalities
• Experience writing detailed study plans, SOPs, and IACUC protocol amendments
• Comfortable with data analysis tools including GraphPad Prism and Microsoft Office

Base Salary Range: $106,000 - $123,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

If you're excited to build a platform that combines DNA and protein multiplexing technologies, please reach out to careers@manifold.bio.

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.