Bench Scientist - II (Antibody discovery)

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Title-Bench Scientist - II (Antibody discovery)
Location-Cambridge ,MA ,USA, 02140
Duration- 12 months contract 

• Biomedicine Design's Endogenous Antibody Discovery Group is seeking a Senior Associate Scientist (contingent worker) to support antibody discovery projects focused on B cell-based workflows.
• This role will contribute to therapeutic antibody discovery campaigns using rodent immunization, serum titer screening, B cell sorting by flow cytometry, immune library generation, and hybridoma-based methods.
• The successful candidate will execute established laboratory workflows that support immunization-based discovery, including rodent selection,immunization strategies (protein, cell-based, and genetic), serum response evaluation by ELISA, flow cytometry,VH/VL molecular cloning, immune library generation and quality control, electrofusion, and hybridoma culture and screening.
• The role will also contribute to the evaluation and implementation of new technologies that enhance immunization and flow cytometry-based antibody discovery workflows in collaboration with other group members.
• The successful candidate should bring hands-on experience and technical capability in several of the following areas, aligned with the responsibilities of the role:
• Hands-on experience supporting antibody discovery workflows, including flow cytometry, B cell-based methods, or hybridoma-based screening.
• Working knowledge of molecular biology techniques such as PCR, cloning, and immune library generation or related sample preparation workflows.
• Experience with laboratory documentation, data organization, and communicating experimental results clearly to project teams.
• Strong laboratory organization skills, including reagent handling, inventory support, and maintaining materials needed for experimental workflows.

Responsibilities:

• Provide laboratory support for therapeutic antibody discovery campaigns using flow cytometry, immune library generation, and hybridoma-based methods.
• Execute established workflows to support rodent immunization studies, serum titer screening, B cell sorting, molecular cloning, and related sample processing activities.
• Maintain reagent inventories, prepare laboratory materials, and ensure operational readiness for discovery activities.
• Document experimental procedures, results, and observations accurately in laboratory records and internal data systems.
• Summarize data and communicate key findings, experimental progress, and campaign outcomes to project teams.

Nice-to-have skills:

• Experience with flow cytometry-based analysis or cell sorting.
• Experience with laboratory automation or high-throughput workflows.
• Experience working with rodents, particularly mice, in a research setting.
• Experience working with hybridoma generation, culture, or screening workflows.

Qualifications:

• Bachelor's degree in biology, immunology, molecular biology, biochemistry, or a related scientific discipline, with at least 2 years of full-time laboratory experience in an academic or industry setting.

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