Bioinformatics Analyst

Job Ref: JR-251

Location: 450 Brookline Ave BOSTON, MA 02215

Category: IT Informatics

Employment Type: Full time

Work Location: Boston

Job Posting Location:

Salary: $58,400.00 - $80,400.00 per year

Overview

A computationally-oriented team led by Rameen Beroukhim and Simona Dalin at the Dana-Farber Cancer Institute and Broad Institute seeks a computational associate to join in efforts to develop and apply cutting-edge genomic technologies to characterize genomic rearrangements in cancers and normal tissues and better understand how errors in double strand break DSB repair result in these rearrangements.

Projects include:

1. Identifying sequence features that influence the formation of genomic rearrangements based on data from thousands of tumors and matched normal samples.
2. Applying sophisticated statistical approaches to determine relationships between the presence of specific rearrangements and genetic-pharmacologic vulnerabilities in cancer cell lines.
3. Developing new analysis methods for a novel experimental technique developed in our laboratory to identify subclonal rearrangements in tumor samples.

This individual will contribute to a lively team and wider community of laboratory scientists, computational biologists, cancer geneticists, and software engineers dedicated to discovering and understanding the alterations in the cancer genome and discovering cancer vulnerabilities that could lead to new therapeutics.

We are looking for a person who will lead their projects thinking independently and making original intellectual contributions. We welcome all levels of input from our computational associates, including input on the conduct of analyses but also on new analyses to conduct and new questions to ask. Computational associates in our laboratory regularly present their own work and contribute to the writing of papers and grant applications.

We view a computational associate as a mentored training position with a primary goal being the professional development of our CAs. Prior CAs have successfully pursued a variety of subsequent career directions, including obtaining MDs, PhDs, and MD-PhDs on the paths to careers in both academia and industry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life-changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds and design programs to promote public health, particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, educate tomorrows physician-researchers, and work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

• Interprets complex biological information
• Performs tasks to reduce and consolidate output from software
• Prepares data for utilization by other scientists
• Monitors new data from public databases, finds, and loads missed data, cleans, loaded data to satisfy quality control criteria
• Must be able to query various sources for the information needed, i.e., the Web, publications, and internal DFCI resources
• Directs and guides DNA, RNA, and protein sequence database searches and the computational analysis of resulting data
• Implements end-users needs in database searching and integration
• Maintains the computational infrastructure and controls the flow of samples and information for large-scale studies
• Recognizes and reports problems with the data management process and fixes the problems whenever possible

Knowledge, Skills, and Abilities Required

• Familiarity with simple programming using Perl, Python, or Java
• CC statistical programming using R or related tools
• Web-development and database query through SQL
• Familiarity with principles of experimental design and modern data analysis paradigms
• Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts
• Excellent analytical, organizational, and time management skills

Minimum Job Qualifications

• The position requires a bachelors degree with an MS preferred or a PhD in bioinformatics, computer science, or life sciences
• Candidates should have 0-2 years of relevant experience and be able to perform primary duties under close to moderate supervision

Supervisory Responsibilities

• In most cases, these positions would not have supervisory responsibilities
• Level III may or may not provide workflow direction to subordinates and serve as a mentor to junior staff

Patient Contact: None

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

EEO Poster

Pay Transparency Statement

The hiring range is based on market pay structures with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidates relevant experience, skills, and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).