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Biologist

Integrated Resources, Inc

Boston, MA

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JOB DETAILS
SKILLS
ADP, Antibodies, Asepsis, Assay Development, Assays, Automation, Biochemistry, Biology, Cell Cultures, Communication Skills, Customer/Client Research, Data Analysis, Detail Oriented, Diabetes, Disease, Disease Prevention and Control, Drug Development, Drug Discovery, Establish Priorities, Genetics, International Health, Laboratory, Medical Products, Multitasking, Obesity, Pharmacology, Presentation/Verbal Skills, Real-time PCR (qPCR), Record Keeping, Small Molecules, Team Player, Volunteer Experience, Writing Skills
LOCATION
Boston, MA
POSTED
15 days ago
R3-R4 In vitro Pharmacologist, CardioMetabolic Research (Boston)
At Client, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to Client and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We re looking for people who are determined to make life better for people around the world.
The CardioMetabolic Research (CMR) of client focuses on the discovery of biologic, small-molecule, and genetic therapeutics for the treatment of diabetes, obesity, and associated complications.
We are seeking a skilled, motivated, and versatile individual to help build a highly collaborative, successful drug discovery and development team within the CMR group in Boston. The ideal candidate should possess a solid background in cell culture and cell-based functional assays, playing an essential role in advancing our discovery initiatives and pipeline projects centered on anti-obesity therapeutics. In this role, the candidate will support assay development and perform established assays to validate new Clients and characterize the in vitro functions of Client therapeutics. Furthermore, the candidate will handle setting up essential laboratory capabilities and work with other scientists both within and across departments to meet project and departmental objectives.
Interested in exploring innovative science? Apply now to join the Client Team.
Key position requirements/responsibilities include:
Technical/scientific skills. Expertise in the following is a must-have:
  • Aseptic cell culture techniques with mammalian cells.
  • Transient transfections and generation of stable cell lines.
  • Development of cell-based functional assays, biochemical and enzymatic assays and screening of Client therapeutics in 96-/384-well plate formats at a single concentration or in a concentration/response manner.
  • Knowledge of basic pharmacology (e.g. concentration/response curves, determination of binding affinity, potency, Hill s slope and in vitro efficacy). Mechanism of action studies of drugs.
  • Experience with colorimetric, luminescence and fluorescence-based readouts, including HTRF. Proficient in operating plate readers, liquid handling robots and assay automation.
  • Design, develop, and optimize in vitro enzymatic assays e.g., ADP-Glo, Kinase-Glo assays
  • Gene expression studies by qPCR, western blot and FACS techniques.
Soft skills:
  • Proficient oral and written communication skills and ability to work both independently and in teams.
  • Requirement for accurate record keeping and independent data analysis. Will perform work in full compliance with Client Research Policies and complete all required training activities in the timeframe specified.
  • Attention to detail and ability to prioritize work on multiple projects, timelines and company goals.
  • Eager to grasp fundamental principles, swiftly acquire new abilities, and adjust to Client challenges.
Minimum qualifications:
  • B.S. and/or M.S. in biology, pharmacology, biochemistry or related field.
  • 8-10 years of laboratory experience.

Additional Skills/Preferences
Experience/expertise with the following is a plus:
  • Native cell lines and primary cell cultures, iPSCs, co-cultures, 3D cultures.
  • Industry experience.
  • Exposure to multiple therapeutic Client classes (e.g. membrane receptors, including G-Protein Coupled Receptors or GPCRs, enzymes, transporters, etc.) and multiple modalities (small molecules, pepProducts, antibodies, siRNAs, etc.).
  • Experience with ELISA assays.
  • Working knowledge or background in cardiometabolic diseases.

About the Company

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Integrated Resources, Inc

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