Biomarkers Research Lab Scientist (Ligand Binding Assays)

Job Description

Company Overview:

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. Our teams bring together deep scientific expertise, advanced technologies, and a commitment to improving patient outcomes through discovery, development, and delivery of innovative therapies. Within Vertex, the Biomarkers organization plays an important role in advancing clinical development through biomarker research, assay development, and cross-functional collaboration.

Role summary:

Vertex is seeking a hands-on Biomarkers Research Lab Scientist to develop and optimize biomarker assays that support clinical trials at Vertex. This individual will design and execute experiments to characterize novel biomarkers in human biofluids and tissues. This role offers the opportunity to contribute to innovative clinical biomarker studies while collaborating closely with members of the Biomarkers lab team and, as needed, with Research, Quality, and Biomarker Leads. The ideal candidate brings strong laboratory experience, effective communication skills, and a collaborative approach.

Key Duties & Responsibilities:

• Develop innovative biomarker assays for clinical studies at Vertex through hands-on laboratory work

• Characterize biomarkers in human biofluids and tissues and evaluate assay feasibility

• Perform mock validation experiments and contribute to the generation of data packages supporting assay readiness

• Partner with members of the biomarkers group to support assay transfer to CROs and external laboratories, including technical handoff and troubleshooting

• Analyze, interpret, and present experimental results to internal stakeholders and project teams

Required Education and Qualifications:

• Ph.D. or equivalent degree with 0-3 years of relevant post-doctoral employment experience, or

• Master's degree or equivalent degree with 3+ years of relevant employment experience, or

• Bachelor's degree or equivalent degree with 6+ years of relevant employment experience

• Hands-on experience developing ligand binding assays for translational or clinical applications

• Strong laboratory experience in molecular biology and cell biology

• Effective communication and interpersonal skills, with proven ability to work effectively as a member of a multidisciplinary team

Technical Skills Required:

• Method development and validation experience in ligand binding assays, including immunoassays and ELISA

• Biomarker assay development, optimization, and troubleshooting

• Western blot

• Protein labeling and quantification

• Molecular biology techniques

• Cell biology techniques

• Data interpretation and scientific presentation skills

Preferred Skills:

• Experience with cell culture and cell-based assays

• Experience with genomic assays such as qPCR, ddPCR, and NGS

• Experience with flow cytometry assays

Benefits:

• Opportunity to contribute to innovative biomarker research supporting clinical development

• Exposure to translational and clinical biomarker assay work within a collaborative environment

• Competitive compensation and comprehensive employee benefits

Pay Range:

$102,400 - $153,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com