Cardiometabolic Research Biologist

Pay Range: $52.28hr - $57.28hr

Job Overview:

The Cardiometabolic Research (CMR) team is focused on the Client and early phase clinical development of biologic, small molecule, oligonucleotide, and cell therapies for treatment of diabetes, obesity, cardiovascular disease, and associated metabolic disorders. The Data Science team within CMR is seeking someone with wide-ranging experience in next-generation sequencing library preparation to help achieve research goals. The successful candidate will be responsible for RNA-seq, scRNA-seq, snRNA-seq, and other types of -seq library preparations for all CMR groups. This will be a cross-therapeutic area role encompassing opportunities to impact science in the team. The candidate will conduct experiments to identify and validate drug targets, support assay design, optimization, validation, and data analyses, design and execute molecular and cell biology experiments, troubleshoot and analyze complex data in support of drug Client projects, and present results and conclusions both orally and in writing.

Job Requirements:

• B.S. and/or M.S. in biological or biochemical sciences (or a related field) with 3-5 years of laboratory research experience.
• Molecular biology mastery of nucleic acid extraction and purification, quantification, NGS library preparation/QC, and qPCR.
• Strong background in NGS technologies and their applications, including quantification, sequencing, and data QC (preferably Illumina). Direct experience with RNA-seq (bulk) and amplicon-seq.
• Direct experience with single-cell and single-nucleus RNA-seq library preparation is required. Candidates must be familiar with multiple scRNA-seq/snRNA-seq platforms (e.g., 10X Genomics Chromium, Illumina PIP-seq, ScaleBio, or Parse Biosciences).

Additional Skills/Preferences:

• Familiarity with CRISPR-based gene editing and high-throughput screening is a plus.
• Experience with automation is a plus (Mantis, Integra systems, Liquid Handlers, SPTLabtech Firefly, Tecan, etc).
• Strong organizational, time management, and communication skills.
• Experience with documentation in electronic notebook software.