Director, CRC Strategy & Indication Lead

ROLE SUMMARY

Pfizer Commercial Oncology is introducing the world to the next era of cancer care. With a growing portfolio of novel therapies, industry-leading R&D, and a goal of delivering eight breakthroughs by 2030 across major cancer types, we're translating cutting-edge science into market-shaping impact. Here, you'll partner with exceptional colleagues across scientific, medical, and manufacturing teams, backed by advanced digital and AI-enabled infrastructure and the authority to accelerate medicines from discovery to delivery. Guided by our values of courage, excellence, equity, and joy, you'll have the opportunity to stretch your skills and build a career that evolves with you—across teams, roles, and the Pfizer enterprise. Join us to make history — for patients, for their families, for the future. 

BRAFTOVI is a growth driver in Pfizer Oncology’s Precision Medicine & Thoracic Franchise, and metastatic colorectal cancer is its engine, progressing the BREAKWATER launch. Following full FDA approval and the expanded 1L indication for BRAFTOVI in combination with cetuximab and fluorouracil-based chemotherapy, CRC is expected to remain a growth priority over the next 3–4 years. For BRAF V600E mCRC patients - who face a poor prognosis and a short, high-stakes window from diagnosis to treatment - getting them to test fast, make the results visible to provider, getting the regimen started, and keeping patients on it, changes outcomes. This role owns whether that happens at scale.

This is the senior commercial seat for the CRC indication and the owner of the CRC specific goals. You are expected to set and adapt the overall CRC growth strategy, own the go-to-market model evolution, and carry the indication P&L story end-to-end — topline, NPS, forecasting, latest estimates, and the KPI framework the franchise steers by. You lead the CRC marketing team’s strategy through influence, holding joint accountability with the CRC marketers for delivering one shared set of imperatives. Within that mandate, role is expected to lead Strategic Imperative #3 — preventing unnecessary early discontinuation through proactive HCP and patient support — a new-for-2027 imperative being build from the ground up.

ROLE RESPONSIBILITIES

Lead the CRC strategy and GTM model

• Define, adapt, and drive the overall CRC commercial strategy across the 1L opportunity. BREAKWATER Launch and the treatment journey

• Co-own the go-to-market / promotional-field model and targeting strategy, in partnership with precision-engagement and field-strategy leads

• Lead cross-functional and leadership updates for the indication; represent CRC in franchise strategic planning, OP, and LE

Accelerate CRC Growth

• Responsible for CRC revenue, TRx, and NPS as the accountable indication lead

• Lead the CRC KPI Measurement Framework - instrumenting on new-patient acquisition, leading indicators, and persistence.

• Support CRC forecasting, latest estimates, and phasing

Lead the CRC team and hold joint accountability for the imperatives

• Lead the CRC marketing group, holding shared accountability with indication marketers for delivering the CRC strategic imperatives - testing/actionability, HCP conviction, and consumer workstreams - against one aligned strategy

• Partner across field sales, TLELs, Medical, Patient Services, RC, Legal, Regulatory, analytics, and agencies

Strategic and Tactical Imperative ownership

• Build the strategy to prevent unnecessary early BRAFTOVI discontinuation, addressing the post-first-fill drop-off and persistence gap

• Design proactive HCP and patient/caregiver support infrastructure in partnership with Patient Services, SPP, advocacy, and field

• Translate early persistence and AE signals into a measurable, ROI-accountable support model

• Own APP strategy across the patient journey and serve as tactical plan lead for the indication

• Ensure tactics ladder to the CRC strategic imperatives and are executed with operating discipline across the matrix

BASIC QUALIFICATIONS

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

• Bachelor’s degree with 8+ years, MBA/MS with 7+ years, or PhD with 5+ years of marketing, commercial, or related experience

• US marketing / commercial experience

• Demonstrated ability to develop, adapt, and execute brand strategy that drives measurable growth

• Ownership of a commercial P&L, forecast, or KPI framework, with strong analytical and business acumen

• Strong project leadership across multiple simultaneous priorities, stakeholders, and timelines

• Proven ability to lead and influence cross-functionally without direct authority

• Excellent verbal and written communication, including with senior leadership

Other Job Details:

• Last Date to Apply for Job: October 07, 2026
• NOT Eligible for Relocation Package
• Position is hybrid and will require to work 2/3 days a week from site

The annual base salary for this position ranges from $176,600.00 to $294,300.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

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