Director or Associate Director, Medicinal Chemistry

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.

KEY RESPONSIBILITIES

• Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates
  

• Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles
  

• Work closely with molecular and cellular biology, pharmacology, computational chemistry,
  

  ADME, and other key functions
  

• Act as liaison between Entos, CROs, and other external partners
  

• Influence the prospective use of computational methods and leverage automated synthesis
  

  and high-throughput experimentation capabilities
  

• Work closely with AI/ML teams to develop and implement relevant predictive models to aid
  

  in the design of new molecules
  

• Communicate project updates clearly and effectively to the broader team and key
  

  stakeholders
  

• Work as a senior member of the Chemistry research group and foster a culture of scientific
  

  excellence, innovation, and teamwork
  

PREFERRED QUALIFICATIONS

• A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery
  

• 
  
  Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
  

• Ability to integrate multiple R&D disciplines into a successful strategic project plan
  

• Experience in leading projects and driving programs through the preclinical development
  

  process
  

• Experience working with computational chemists as part of project team in design of drug targets is required
  

• Strong interpersonal, communication, time management, and leadership skills
  

• Experience mentoring or leading junior chemists
  

• Creative problem solving and management of relationships with several stakeholders within
  

  and beyond the company
  

Requirements

PREFERRED QUALIFICATIONS

• A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery
  

• 
  

  
  
  Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
  

  
  

• Ability to integrate multiple R&D disciplines into a successful strategic project plan
  

• Experience in leading projects and driving programs through the preclinical development
  

  process
  

• Experience working with computational chemists as part of project team in design of drug targets is required
  

• Strong interpersonal, communication, time management, and leadership skills
  

• Experience mentoring or leading junior chemists
  

• Creative problem solving and management of relationships with several stakeholders within
  

  and beyond the company
  

Benefits