LC-MS Principal Scientist

Description

As an LC-MS Principal Research Scientist, you will serve as an industry expert for pre-clinical GLP bioanalytical study method development, validation, sample analysis utilizing triple quadrupole LC-MS systems. You will serve as the expert for ADCs and large molecule LC-MS/MS analytical assays and sample preparation. Responsible for direct interaction with clients, report writing, and adherence to regulatory guidelines. You will collaborate with other scientists, analysts, and departments in a team-oriented environment. You will possess knowledge and experience in a Good Laboratory Practice (GLP) environment and be able to adhere to GLP guidelines and practices.

• Provide technical and scientific expertise for small and large molecule analysis via LC-MS/MS.
• Ensure all work is operating in full compliance to GLP requirements, protocols, and SOPs.
• Maintain open and direct communication and attend recurring calls with clients as needed.
• Serve as principal investigator or contributing scientist for LC-MS/MS studies.
• Prepare all necessary driving documents for in-lab analysis.
• Complete and deliver scientific reports to clients on time
• Prepare materials, including animal blood and tissues, for analytical assays to be run on LC-MS/MS instrumentation
• Maintain and document chain of custody for specimens, reagents, controls, and samples in the laboratory
• Perform the assays according to protocol or other guiding documents with accurate documentation.
• Maintain and update facility records related to the laboratory and its analyses.
• Review laboratory records, procedures, and study data for completeness and accuracy.
• Assist in calibration, optimization, maintenance, and collection of data from analytical instruments.
• Perform routine laboratory maintenance (including cleaning, stocking supplies, equipment maintenance tasks, etc.).
• Document deviations to laboratory procedures and study protocols in a timely manner and provide input for corrective actions.
• Collaborate with internal regulatory departments to ensure quality and compliance oversight on GLP studies.
• Follow Standard Operating Procedures (SOPs), ensure compliance with GLP, FDA"s ICH M10 guidelines, ALCOA+, USDA, and AAALAC guidelines, and can identify areas for improvement.

Qualifications

• Bachelor's degree in Immunology/Biology/Chemistry or other scientific related discipline plus a minimum of 5 years as a Research Scientist with relevant GLP laboratory experience supporting LCMS/MS work.
• Experience in a Good Laboratory Practices (GLP) and CRO environment.
• Experience with LC-MS/MS instrumentation and software.
• Experience with Shimadzu and SCIEX instrumentation.
• Experience with Watson.
• Ability to handle multiple projects, prioritize work, and meet deadlines.

Job Type & Location

This is a Permanent position based out of Everett, WA.

Pay and Benefits

The pay range for this position is $120000.00 - $150000.00/yr.

Health/Dental/Vision Insurance Plans 401(k)/RRSP with Employer Match Paid Vacation and Holidays Paid Sick and Bereavement Leave Employee Assistance & Telehealth Programs Telework when applicable.

Workplace Type

This is a fully onsite position in Everett,WA.

Application Deadline

This position is anticipated to close on Jun 19, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.