Oligonucleotide Scientist II

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. The Position:
We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within the Protein Sciences (PS) department. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.
Key Responsibilities:

• The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology, and oncology, to help build a comprehensive therapeutic discovery strategy.
• Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC, and desalting units.
• Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.