The George Calin laboratory is seeking a highly motivated Postdoctoral Fellow to join a multidisciplinary research program focused on uncovering novel RNA-based mechanisms that drive hepatocellular carcinoma (HCC) and translating these discoveries into therapeutic strategies. This position offers an exceptional opportunity to work at the interface of RNA biology, cancer genomics, and therapeutic development within a collaborative and innovation-driven environment.
All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.
LEARNING OBJECTIVES The postdoctoral fellow will contribute to projects that may focus on the understanding and correct practice of techniques related to the roles of non-coding RNAs in cancer:
1. Clinical and Database Analyses
Evaluate the expression of miR-485-3p and VPS45 and their prognostic significance using
TCGA datasets and clinical samples.
2. Functional Analyses
• Conduct gain- and loss-of-function experiments of miR-485-3p and VPS45 in HCC cell
lines.
• Validate tumorigenic potential using mouse models.
3. Comprehensive RNA Network Analysis
• Utilize large-scale miRNA-seq and CLIP-seq datasets at the Calin lab to identify novel
RNA interaction networks in HCC.
• Functionally validate promising candidates and confirm their clinical relevance in human
tissues and circulating miRNAs.
ELIGIBILITY REQUIREMENTS An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
ADDITIONAL APPLICATION INFORMATION Translational Molecular Pathology Department website:
https://www.mdanderson.org/research/departments-labs-institutes/departments-divisions/translational-molecular-pathology.html
POSITION INFORMATION MD Anderson offers full-time postdoc positions with a
salary ranging from $64,000 to $76,000. depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent
benefits, including medical, dental,
paid time off,
retirement, tuition benefits, educational opportunities, and individual and team recognition
Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.
This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.
http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html