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Postdoctoral Position in Diabetic Fracture Healing, FOXO1, Primary Cilia, and Regenerative Biomaterialsled Position

University of Pennsylvania

Philadelphia, PA

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JOB DETAILS
SKILLS
Bioengineering, Biology, Biomechanics, Cell Biology, Diabetes, Genomics, Histology, Immunology, Mechanical Testing, Molecular Biology, Test Plan/Schedule, Veterinary Medicine
LOCATION
Philadelphia, PA
POSTED
23 days ago


Open to applications from U.S. Citizens and foreign nationals



A postdoctoral position is available in the laboratory of Dr. Dana Graves, University of Pennsylvania, to study why diabetes disrupts fracture healing and to develop a new local therapeutic strategy to restore bone repair. This project builds on compelling data showing that lineage-specific deletion of FOXO1 in chondrocytes or osteoblasts fully rescues diabetes-impaired fracture healing, as measured by histology, microCT, and mechanical testing. We have also found that loss of primary cilia in these same skeletal lineages reproduces key features of diabetic fracture healing. Together, these findings point to a novel FOXO1–primary cilia axis as a central regulator of skeletal repair in diabetes.







The successful candidate will investigate how diabetes-driven FOXO1 activity suppresses ciliogenesis and regenerative signaling in chondrocytes and osteoblasts. The project will use conditional mouse models targeting FOXO1, IFT80, and combined FOXO1/IFT80 deletion; diabetic fracture models; spatial transcriptomics; single-cell RNA sequencing; histology; immunostaining; microCT; and biomechanical testing.







A major translational component will test a newly developed nanofiber hydrogel carrying an IGF-1 mimetic, NFH-IGF, designed for controlled local release at the fracture site. The goal is to determine whether NFH-IGF can restore cilia-dependent signaling, suppress FOXO1 activity, and improve fracture healing in type 1 and type 2 diabetes.











Applicants should have a PhD, MD, DMD, DVM, or equivalent degree in skeletal biology, cell biology, molecular biology, bioengineering, diabetes biology, immunology, or a related field. Experience with mouse models, bone or cartilage biology, fracture healing, imaging, molecular assays, spatial transcriptomics, single-cell RNAseq, or bioinformatics is desirable.



This position offers an opportunity to work at the interface of skeletal biology, diabetes complications, primary cilia signaling, regenerative biomaterials, and high-dimensional genomics, with strong potential for high-impact mechanistic and translational discoveries.



To apply, send a cover letter, CV, and contact information for three references and submit through interfolio.




The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.

About the Company

U

University of Pennsylvania

Penn's beautiful urban campus provides easy access to a range of educational, cultural, and recreational activities. We offer excellent healthcare and tuition benefits for you and your family, as well as generous retirement benefits, professional development opportunities and flexible work options. Penn is a diverse, multicultural learning community at the cutting edge of research and information technology. Click here to read more about why we're a Best Employer. Not only does Penn offer a unique environment within the city of Philadelphia to work, we also provide a wide array of employee benefits. From a competitive retirement program and comprehensive health care options to health promotion and wellness services and tuition assistance, there's a wealth of opportunities and resources available to you at Penn.

Penn is frequently cited as an outstanding employer:

  • Recipient of the 2010 Terri Lynne Lokoff Child Care Foundation Corporate Leadership Award for commitment to supporting worklife balance programs.
  • Selected as a recipient of the 2010 Healthy Workplace Award by the Philadelphia Business Journal and presenting sponsor UnitedHealthcare
  • Recognized as a 2010 Top Workplace by The Philadelphia Inquirer/Daily News.
  • Recipient of the 2009 Vision Award for commitment to workforce diversity and economic inclusion.
  • Selected for Computerworld's 100 Best Places to Work in IT six years in a row!
  • Recognized by the Delaware Valley Association for the Education of Young Children as a 2006 Best Employer for Working Parents
  • Named a Best Place to Work in the November 2007 issue of Philadelphia Magazine.
  • Designated a Best Workplace for Commuters by the National Center for Transit Research
COMPANY SIZE
100 to 499 employees
INDUSTRY
Advertising and PR Services
FOUNDED
1990
WEBSITE
http://www.cmimedia.com/

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