Postdoctoral Researcher - Ellerby lab

# LAB OVERVIEW Dr. Lisa Ellerbys laboratory at the Buck Institute for Research on Aging investigates the molecular mechanisms underlying age-related neurodegenerative diseases and develops novel small molecule and protein therapeutics for brain aging. We employ a rich toolkit including iPSC-derived neurons and organoids, CRISPR/Cas9, single-cell analysis, proteomics, genomics, and phenotypic screening to understand why neurological diseases increase so dramatically with age - and to identify new ways to prevent and treat them.

# POSITION SUMMARY We are seeking a motivated Postdoctoral Researcher to lead a high-throughput screening (HTS) program focused on brain aging and neurodegeneration. This is an exciting opportunity to drive discovery at the intersection of chemical biology, iPSC-based disease modeling, and advanced high-content imaging - with a specific focus on OXR1 and APOE2 biology. The successful candidate will develop and execute screens to identify small molecules that reverse aging phenotypes or build cellular resilience in neuronal models.

# KEY RESPONSIBILITIES

• Develop and lead a high-throughput screening (HTS) effort to identify small molecules that reverse aging to a youthful state or build resilience, with a focus on OXR1 and APOE2 biology.
• Design and execute high-content imaging workflows and Cell Painting-based phenotypic profiling.
• Develop and apply iPSC-derived neuronal and organoid models for disease-relevant screening.
• Operate and integrate complex robotic automation platforms and multi-instrument workflows.
• Analyze complex imaging outputs using Python and R; apply pathway analysis and data visualization tools.
• Collaborate with biologists across the Buck Institute to standardize protocols and experimental design.
• Contribute to peer-reviewed publications as a leading author and apply for fellowship/grant funding.
• Participate in institutional seminars, programs, and the broader Buck Institute scientific community.

# QUALIFICATIONS

## Required

• PhD in Neuroscience, Biology, Chemistry, Chemical Biology, or a related field.
• Hands-on experience with HTS assay development and laboratory automation platforms.
• Experience with high-content imaging and analysis pipelines (e.g., CellProfiler, Columbus, or similar).
• Proficiency in Python and/or R for image and data analysis.
• Demonstrated ability to drive independent research and a strong publication record.

## Highly Desirable

• Experience with iPSC-derived neuronal models or cerebral organoids.
• Familiarity with Cell Painting/image-based morphological profiling.
• Experience with senescence biology, neurodegeneration, or aging-related pathways.

# WHY THE BUCK INSTITUTE? The Buck Institute is the worlds leading independent research institute dedicated to understanding and combatting the diseases of aging. Postdoctoral researchers benefit from a highly collaborative interdisciplinary environment, state-of-the-art core facilities, strong career development programming, and proximity to the vibrant Bay Area biotech ecosystem.

The Buck Institute is an equal opportunity employer committed to fostering a diverse and inclusive workplace. We strongly encourage applicants who will contribute to the diversity of our community.

# COMPENSATION & BENEFITS

• Salary Range: $73,760-81,440 annually, commensurate with experience and qualifications.
• Comprehensive benefits package including health insurance, paid parental leave, childcare assistance, generous paid time off, and a 401(k) with 5% employer match.

# HOW TO APPLY Please submit a CV, a brief statement of research interests (1-2 pages), and contact information for three references.

For Additional Information: Professor Lisa M. Ellerby, Ph.D. [email protected]