Overview A global biopharmaceutical company on a mission to Solve On Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery development and commercialization of proprietary therapeutics Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology Oncology and Inflammation and Autoimmunity Headquartered in Wilmington Delaware Incyte has operations in North America Europe and Asia. Job Summary Primary function The Associate Director Translational Sciences is a senior lab‑embedded translational scientist who leads the design and execution of strategies that bridge preclinical discovery and early clinical development. This role is responsible for converting patient‑derived multi‑omic data generated internally and through external collaborations into actionable assays biomarkers and translational insights that support therapeutic target discovery preclinical de‑risking and dose prediction and optimization. The Associate Director provides scientific and technical leadership by integrating multi‑omic analyses e.g. transcriptomic proteomic and cellular profiling with advanced assay development to define mechanism‑aligned biomarkers and pharmacodynamic readouts that inform target selection exposure-response understanding and early clinical strategy. The role partners closely with Discovery Bioinformatics Biomarker Clinical and other development functions to ensure mechanistic hypotheses and patient‑relevant data are fully integrated into program decisions. This position is intentionally designed as a scientist‑first role emphasizing hands‑on laboratory engagement technology implementation and data interpretation. The Principal InvestigatorAssociate Director will primarily operate as a senior individual contributor with the potential to oversee a small team of laboratory scientists or matrixed contributors over time while remaining actively involved in experimental design assay execution and cross‑functional program support. Essential Functions of the Job Key responsibilities • Lead the design development and implementation of state‑of‑the‑art translational assays and platforms including molecular cellular and multi‑omic technologies. • Drive biomarker discovery and validation from exploratory research through fit‑for‑purpose assay development for preclinical and early clinical use. • Apply advanced technologies e.g. transcriptomics proteomics spatial biology and single‑cell approaches to address key translational and mechanistic questions. • Integrate patient‑derived multi‑omic datasets to support therapeutic target discovery prioritization and validation across oncology and inflammationautoimmune programs. • Collaborate with bioinformatics and data science partners to translate complex multi‑omic data into biologically and translationally actionable insights. • Provide translational input to preclinical development programs including mechanism‑of‑action confirmation exposure-response evaluation and dose optimization strategy. • Contribute to early toxicology assessment and de‑risking including identification of safety‑relevant biomarkers and translational readouts. • Design and utilize in vivo ex vivo and human‑relevant model systems including patient‑derived samples organoids primary cells and PBMC‑based platforms. • Ensure scientific rigor reproducibility and high‑quality data interpretation across all assays and experimental approaches. • Provide technical leadership and mentorship within the Translational Biomarker Discovery Lab including hands‑on experimental guidance and oversight of external collaborations or CROs as needed. Qualifications Minimal acceptable level of education work experience and competency • PhD or equivalent in Oncology Molecular Biology Systems Biology Immunology or a related life sciences discipline • 6-10 years of experience in translational research within pharma biotech or a comparable research environment • Strong demonstrable expertise in assay development optimization and implementation • Hands on experience with advanced molecular and cellular technologies and multi omic platforms • Proven ability to integrate biological data across multiple modalities to inform discovery and translational decisions • Experience working with human samples and clinically relevant model systems • Strong scientific communication skills and ability to collaborate effectively in matrixed teams Preferred • Experience supporting biomarker strategies for early clinical programs • Familiarity with oncology andor inflammatoryautoimmune disease biology • Experience interacting with toxicology DMB or CQP functions • Comfort working in a role that combines scientific independence with focused team oversight rather than large scale management Disclaimer The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties responsibilities and qualifications. Management reserves the right to change or modify such duties as required. Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer. We Respect Your Privacy Learn more at httpwww.incyte.comprivacy-policy The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate. During the process you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process here. You may have the right to access delete restrict edit move or object to the use of your personal data. 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