Principal Research Scientist – LC-MS/MS Bioanalysis
Everett, Washington | Relocation Assistance Available
RPM ReSearch has partnered with a leading preclinical Contract Research Organization (CRO) to identify a Principal Research Scientist – LC-MS/MS to join its growing bioanalytical sciences team. Our client partners with pharmaceutical and biotechnology companies to support the discovery and development of novel therapeutics through high-quality GLP bioanalytical services. This is an opportunity to join a collaborative scientific organization where your expertise will directly contribute to advancing new therapies toward the clinic.
Important Qualification
Experience supporting Antibody-Drug Conjugate (ADC) bioanalysis is required for this position.
While we welcome applicants with strong LC-MS/MS backgrounds, this particular opportunity requires prior experience developing, validating, and/or supporting LC-MS/MS methods for ADCs within a GLP pharmaceutical or CRO environment. Candidates without ADC experience are unlikely to be a match for this role.
About the Role
As the Principal Research Scientist, you will serve as the technical and scientific expert for LC-MS/MS bioanalysis, with particular emphasis on ADCs and large molecule assays. You'll provide scientific leadership across method development, validation, sample analysis, study execution, and client interactions while collaborating closely with cross-functional scientific and regulatory teams in a GLP environment.
Key Responsibilities
- Provide scientific leadership for LC-MS/MS bioanalysis supporting both small and large molecule programs, including ADCs.
- Lead method development, validation, troubleshooting, and sample analysis for GLP bioanalytical studies.
- Serve as Principal Investigator or lead scientist on client-sponsored studies.
- Partner directly with pharmaceutical and biotechnology clients, providing technical expertise and scientific consultation.
- Prepare and review scientific reports, study documentation, and laboratory records.
- Ensure compliance with GLP regulations, FDA guidance, SOPs, and quality standards.
- Collaborate with Quality, Regulatory, and laboratory teams to support successful study execution and continuous process improvement.
Qualifications
The successful candidate will have:
- Bachelor's, Master's, or Ph.D. in Chemistry, Biology, Immunology, or another relevant scientific discipline.
- Significant hands-on experience with LC-MS/MS instrumentation and bioanalytical method development.
- Demonstrated experience supporting Antibody-Drug Conjugate (ADC) bioanalysis.
- Experience working within a GLP-regulated CRO or pharmaceutical environment.
- Experience serving as a Principal Investigator, Senior Research Scientist, or comparable scientific leadership role.
- Strong scientific writing, data interpretation, and client communication skills.
- Ability to manage multiple studies while maintaining exceptional scientific quality and regulatory compliance.
Preferred Experience
Experience with one or more of the following is highly desirable:
- Large molecule LC-MS/MS assays
- Shimadzu and/or SCIEX instrumentation
- Watson LIMS
- FDA ICH M10 guidance
- Bioanalytical method validation in support of drug development
Why Join?
- Join a respected and growing preclinical CRO supporting innovative pharmaceutical and biotechnology companies.
- Play a highly visible scientific leadership role with direct client interaction.
- Work on cutting-edge therapeutics, including Antibody-Drug Conjugates and other advanced modalities.
- Collaborate with an experienced team of scientists in a GLP environment committed to scientific excellence.
- Competitive compensation, comprehensive benefits, and relocation assistance are available for qualified candidates.
Interested?
Apply directly or send your résumé to: Marina@RPMResearch.Solutions
Know someone who would be an excellent fit? We always appreciate referrals and would be grateful if you shared this opportunity with your network.