Principal Research Associate/Associate Scientist, Molecular Assembly

Position Summary:

TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Principal Research Associate/Associate Scientist in the Molecular Assembly team, supporting our novel target identification and validation workflow in house. The ideal candidate should have relevant experience in cloning techniques and enjoy a fast-paced, collaborative, and vibrant culture. A team player with a sense of urgency will thrive in this role.

Responsibilities:

• Collaborate with other scientists to design and build various constructs and vectors in support of target/TCR discovery efforts.
• Assemble large libraries of peptides, TCRs, etc. using specialized cloning protocols.
• Perform medium- to high-throughput cloning experiments to support discovery efforts in target identification and validation.
• Analyze and interpret cloning and screening data (e.g., sequencing, functional assays) to guide construct design and optimization.
• Troubleshoot complex cloning and library construction challenges and propose scalable solutions.
• Lead group efforts towards technology development and improvement.
• Implement and optimize high-throughput workflows, including automation where applicable.
• Train co-workers on molecular cloning techniques.
• Maintain accurate and well-documented experimental records (e.g., ELN) to ensure data integrity and reproducibility.

Requirements:

• PhD with 0-2+ years of industry experience; Masters degree with 5-7+ years of relevant lab experience, preferably in the biopharmaceutical or biotechnology industry.
• Hands-on experience in a variety of molecular cloning techniques, including Gibson Assembly, Golden Gate Assembly, Gateway recombination, etc.; experience constructing large-scale libraries is desirable.
• Highly organized with very strong attention to detail.
• Demonstrated ability to manage multiple projects and meet deadlines in a fast-paced environment.
• Ability to work both independently and collaboratively and adapt quickly to changing priorities.
• Scientific creativity, critical thinking, and problem-solving skills.
• Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.
• Familiarity with sequence analysis tools, NGS, and basic bioinformatics workflows preferred.
• Knowledge of immunology concepts, especially TCR biology and antigen recognition, is preferred.