Research Assistant 3

Salary Grade

Case Western Reserve University is committed to providing a transparent estimate of the salary range available for this position at the time of its posting. The salary range is between $46,035 and $58,234, depending on qualifications, experience, department budgets, and industry data.

Employees receive more than just a paycheck. University employees enjoy a comprehensive benefits package that includes excellent healthcare, retirement plans, tuition assistance, paid time off, and a winter recess.

Job Description

POSITION OBJECTIVE

Working under limited supervision, the Research Assistant 3 will support chemical biology and chemical proteomics research focused on discovery of small-molecule ligands and characterization of protein function in cancer and immunology-related systems. The position will design and execute experimental workflows, coordinate laboratory operations, and contribute to data analysis and method development. This role directly supports the labs mission to develop chemical tools to uncover new biology and therapeutic opportunities. This position will work with animal models and animal-derived samples as part of approved research protocols.

ESSENTIAL FUNCTIONS

• Design and independently execute biochemical, cell-based, and animal-related experimental workflows, including proteomics sample preparation, functional assays, and processing of animal-derived biological samples, to support ongoing research projects. (20%)
• Analyze and interpret biochemical, cell-based, and animal-study data, including preparation of figures and summaries for internal discussion and publication; apply statistical and quantitative methods where appropriate to assess experimental quality, reproducibility, and biological significance. (20%)
• Devise, optimize, troubleshoot, and validate new protocols and techniques for research projects requiring advanced skill and training, including proteomics sample preparation, ligand-engagement assays, cell-based functional assays, and animal-related sample processing workflows; evaluate protocol adequacy by testing controls, reproducibility, signal-to-noise, data quality, and suitability for downstream analysis. (10%)
• Coordinate laboratory operations, including reagent preparation, inventory management, equipment maintenance, animal protocol documentation and support as applicable, and compliance with institutional safety, animal research, and regulatory standards. (20%)
• Collaborate closely with the principal investigator to plan biochemical, cell-based, and animal-related experiments, prioritize research directions, and implement new techniques; contribute to experimental design, strategy, and evaluation of feasibility. (10%)
• Train and supervise junior personnel (students or technicians) in laboratory techniques, standard operating procedures, and approved animal-related procedures as applicable; ensure reproducibility, data quality, and adherence to safety and animal research compliance requirements. (10%)
• Maintain detailed and organized experimental records, animal-related study documentation as applicable, and databases to ensure data integrity, regulatory compliance, and reproducibility. (6%)

NONESSENTIAL FUNCTIONS

• Participate in lab meetings, seminars, and training activities. (1%)
• May monitor the laboratory budget by tracking routine research expenditures, reviewing supply and animal-related service costs, maintaining purchasing records, and alerting the PI to budgetary or purchasing issues. (2%)
• Perform other duties as assigned. (1%)

CONTACTS

Department: Continuous interaction with principal investigator and lab members to coordinate research activities and share data.

University: Occasional interaction with core facilities (e.g., proteomics core, animal cores) to coordinate experiments.

External: Occasional interaction with collaborators or vendors for technical support and materials procurement.

Students: Moderate interaction with undergraduate or graduate trainees for experimental work.

SUPERVISORY RESPONSIBILITIES

May train undergraduate students and junior lab members. No direct hiring or disciplinary authority.

QUALIFICATIONS

Experience: 3 to 5 years of relevant laboratory research experience in molecular biology, biochemistry, or related biomedical field. Experience in cell culture, protein assays, or in vivo models preferred.

Education/Licensing: Bachelors degree in biochemistry, molecular biology, chemistry, or related field required.

REQUIRED SKILLS

• Strong experimental skills in molecular biology, biochemistry, or cell biology. Experience in purchasing and overseeing reagent inventory and equipment. Strong communication and teamwork skills.
• Relies on instructions and pre-established guidelines to perform the functions of the job.
• Willingness to learn and work with artificial intelligence (AI) tools and technologies.
• Ability to demonstrate successful support, education, and advocacy for all students, aligned with the values, mission, and messaging of the university, while adhering to the staff policy on conflict of commitment and interest.
• Ability to meet consistent attendance.
• Ability to interact with colleagues and supervisors face to face.
• Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
• Must demonstrate compassion for animals within Case Western Reserve University facilities and dedication to the Animal Resource Centers mission. Must handle animals with care and respect at all times.
• Must be able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals.
• Previous experience working with animals preferred.

WORKING CONDITIONS

Work is performed primarily in a laboratory environment with exposure to biological and chemical hazards. Requires use of personal protective equipment (PPE). May involve handling cell lines, chemical reagents, and standard laboratory instrumentation. Occasional lifting of laboratory materials (up to ~30 lbs.).

Case Western Reserve Universitys animal facilities are accredited by the Associate for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the ¿Guide for the Care and Use of Laboratory Animals¿ appropriate Federal Animal Welfare Regulations, and the Public Health Service ¿Policy on the Humane Care and Use of Laboratory Animals.¿ This position and all animal research personnel are subject to internal compliance to the School of Medicines Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

Hybrid Eligibility

This position is eligible for hybrid work arrangement up to two remote days per week at the discretion of the department. New employees may begin a hybrid schedule upon approval from the supervisor, successful completion of an orientation period and signing the remote work checklist certification form.

EEO Statement

Case Western Reserve University is an equal opportunity employer. All applicants are protected under federal and state laws and university policy from discrimination based on race, color, religion, sex, sexual orientation, gender identity or expression, national or ethnic origin, protected veteran status, disability, age and genetic information.

Reasonable Accommodations

Case Western Reserve University complies with the Americans with Disabilities Act regarding reasonable accommodations for applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the CWRU Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicants will be made on a case-by-case basis.

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