Research Associate II (2026-50342)

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When you join the UMass Chan Medical School team, you join us in advancing together to improve the health and well-being of our diverse communities throughout Massachusetts and across the US and the world. Together, we lead in education, research, health care delivery, and public service. Your life's work is more than a career. It's an expression of your passion, intellect, skill, and drive. UMass Chan"s commitment to excellence, innovation, competitive benefits, and work-life integration will allow you to build a professionally rewarding career as we work together to better or improve the health of people around the globe.

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Research Associate II

Job Number: 2026-50342

Category: Research

Location: Worcester, MA

Shift: Day

Exempt/Non-Exempt: Exempt

Business Unit: UMass Chan Medical School

Department: School - Diabetes Center of Excellence - W477000

Job Type: Full-Time

Union Code: Non Union Position -W60- Non Unit Professional

Num. Openings: 1

Post Date: July 20, 2026

Work Location: 100% Onsite

Salary Minimum: USD $44,000.00/Yr.

Salary Maximum: USD $47,000.00/Yr.

Research Associate - Stem Cell Biology, Genome Engineering, and Genomics

The Maehr Lab at UMass Chan Medical School invites applications for a Research Associate position supporting an NIH-funded program focused on engineering stem cell-derived islets for immune tolerance.

Our laboratory combines human pluripotent stem cell differentiation, CRISPR-based genome and epigenome engineering, next-generation sequencing, single-cell genomics, and immunology to develop stem cell-derived islets that resist autoimmune and allogeneic immune responses while preserving beta-cell identity and function.

Position Overview

The Research Associate will support projects involving human pluripotent stem cell culture and differentiation, molecular cloning, gene targeting, immune assays, and genomic profiling. The successful candidate will work with experimental and computational scientists to generate and characterize engineered stem cell lines and assess their differentiation, function, molecular state, and immune compatibility.

Qualifications

Applicants should have a bachelors or masters degree in biology, molecular biology, cell biology, genetics, genomics, bioengineering, immunology, or a related field.

Experience in one or more of the following areas is preferred:

• Human pluripotent stem cell culture and directed differentiation.
• Molecular cloning and CRISPR-based gene targeting.
• RNA-seq, ATAC-seq, ChIP-seq, or single-cell omics.
• Flow cytometry, imaging, or immune-cell assays.
• Pancreatic beta-cell or islet biology.

Prior experience in every area is not required. Candidates with strong experience in one relevant area and an interest in learning complementary approaches are encouraged to apply.

ESSENTIAL FUNCTIONS:

• Perform laboratory experiments and may be responsible for a single research project
• Utilize all software relevant to experiment and equipment used
• Interpret data, form conclusions and decide on next steps with a degree of independence while under the direction of the PI or designee
• Maintain accurate records, may modify protocols with the approval of the PI or designee
• Review literature, publications and grants relevant to assigned projects
• Record results according to established lab, sponsor & university protocol
• Assist with performing data analysis and/or mathematical computations
• Maintain a detailed lab notebook according to lab practice
• Present findings at lab/group meetings
• Monitor laboratory supply levels and order as noted
• May assist with laboratory equipment service contracts and monitor maintenance on laboratory equipment
• Prepare and label buffers, media, solutions, etc.
• Assist with and comply with all safety regulation and infection control standards
• Train on IACUC, IRB, EHS, Radiation safety protocols
• Comply with all applicable state, federal university, and sponsor policies and agreements
• Provide support with identifying problems and challenges, propose resolutions, implement appropriate solutions
• May assist with the training of new lab personnel
• Provide support with drafting standard operation procedures in compliance to EHS regulation specific for the lab
• May assist with drafting manuscripts sections
• Perform other duties as required

REQUIRED QUALIFICATIONS:

• Bachelors degree in Biological or Natural Science and 18 months of relevant research experience or a related Masters degree.
• Knowledge of Microsoft Office products
• ability to analyze complex visual data in a quantitative and objective manner
• Ability to work in a team environment

Research Environment

The Maehr Lab is part of the Program in Molecular Medicine and the Diabetes Center of Excellence at UMass Chan Medical School. The laboratory offers a highly collaborative environment spanning stem cell biology, immunology, functional genomics, epigenomics, computational biology, and regenerative medicine.

Posting Disclaimer:

This job posting outlines the primary responsibilities and qualifications for the role but is not intended to be an exhaustive list. Duties and expectations may evolve in response to the needs of the department and the broader institution.

In alignment with our commitment to pay transparency, the base salary range for this position is listed above (exclusive of benefits and retirement). At UMass Chan Medical School, final base salary offers are determined based on a combination of factors, including your skills, education, and relevant experience. We also consider internal equity to ensure fair and consistent compensation across our teams.

Please note that the range provided reflects the full base salary range for this position. Offers are typically made within the midrange to allow for future growth and development within the role.

In addition to base pay, UMass Chan offers a comprehensive Total Rewards package, which includes paid time off, medical, dental, and vision coverage, and participation in a 401(a)-retirement plan, with the option to contribute to a voluntary 403(b) plan.

UMass Chan welcomes all qualified applicants and complies with all state and federal anti-discrimination laws.

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