Research Associate

University of Pennsylvania

Philadelphia, PA

JOB DETAILS
LOCATION
Philadelphia, PA
POSTED
16 days ago


The Department of Radiation Oncology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for a Research Associate position in the Academic Support Staff. This appointment will be initially for one (1) year and continuation during that time period and renewal are based on satisfactory performance and availability of funding (limited to three (3) years). Expertise is required in the specific area of Tumor biology, preferably in radiation biology/oncology is required. Work with rodents is also required. Experience with growing of tissue organoids, and performing complex immunohistochemical and immunofluorescence analyses on fixed/embedded tissue is strongly recommended. Experience inscRNAseq analysis is a plus. Applicants must have a Ph.D. or equivalent degree. Small animal training certification is required.



Responsibilities may include engagement in research investigating the role of Ultra-High-Dose Rate ("FLASH") radiotherapy in normal and tumor response in head and neck cancer models. Specifically, the role will be engaged in injecting HNSCC cells (both HPV+ and HPV-) in the oral cavity of syngeneic mice, and irradiating them with Proton FLASH or Standard radiation. The impact of these treatments on tumor growth as well as normal tissue toxicity (fibrosis, hyposalivation, atrophy of salivary glands etc) will be assayed. Furthermore, normal tissue and tumor organoids will be developed from mouse models as well as patients with HNSCC-these organoids will be used to determine the impact of FLASH RT +/- DNA damage repair inhibitors on the therapeutic window. The successful candidate is also expected to perform analyses such as scRNAseq and bioinformatics and perform mechanistic studies pertaining to the role of Ferroptosis in normal and tumor tissue response to these treatments. Finally, the RA will be expected to write first drafts of manuscripts and apply for funding form several Institutions and foundations, including the NIH, ACS and AACR.



The successful applicant will have an opportunity to be trained in cutitng edge research on FLASH and HNSCC biology, publish in high-impact journals and receive mentoring in career transition toindependence through grant writing workshops, attending and presenting their research findings at national and international meetings.






The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.

About the Company

U

University of Pennsylvania

Penn's beautiful urban campus provides easy access to a range of educational, cultural, and recreational activities. We offer excellent healthcare and tuition benefits for you and your family, as well as generous retirement benefits, professional development opportunities and flexible work options. Penn is a diverse, multicultural learning community at the cutting edge of research and information technology. Click here to read more about why we're a Best Employer. Not only does Penn offer a unique environment within the city of Philadelphia to work, we also provide a wide array of employee benefits. From a competitive retirement program and comprehensive health care options to health promotion and wellness services and tuition assistance, there's a wealth of opportunities and resources available to you at Penn.

Penn is frequently cited as an outstanding employer:

  • Recipient of the 2010 Terri Lynne Lokoff Child Care Foundation Corporate Leadership Award for commitment to supporting worklife balance programs.
  • Selected as a recipient of the 2010 Healthy Workplace Award by the Philadelphia Business Journal and presenting sponsor UnitedHealthcare
  • Recognized as a 2010 Top Workplace by The Philadelphia Inquirer/Daily News.
  • Recipient of the 2009 Vision Award for commitment to workforce diversity and economic inclusion.
  • Selected for Computerworld's 100 Best Places to Work in IT six years in a row!
  • Recognized by the Delaware Valley Association for the Education of Young Children as a 2006 Best Employer for Working Parents
  • Named a Best Place to Work in the November 2007 issue of Philadelphia Magazine.
  • Designated a Best Workplace for Commuters by the National Center for Transit Research
COMPANY SIZE
100 to 499 employees
INDUSTRY
Advertising and PR Services
FOUNDED
1990
WEBSITE
http://www.cmimedia.com/