RESEARCH ASSOCIATE/STUDENT

Join an exciting, multidisciplinary PhD program that offers hands-on training from day one, bridging cutting-edge laboratory science with clinical research. We are seeking motivated and dedicated doctoral students for the Neuroscience Ph.D. program at the Roskamp Institute, which currently has openings for a 4-year Ph.D. project in Alzheimer's disease (AD) research.

Roskamp Institute projects are all focused on translational research, with analysis of clinical samples to define the conditions under investigation, and extensive characterization of relevant preclinical models in order to identify and develop diagnostic strategies and therapeutic targets.

This PhD student will join our translational team investigating the mechanisms by which genetic and metabolic factors influence cerebrovascular decline and late-onset Alzheimer's disease (LOAD). Our research integrates cross-scale validation using pharmacologic and genetic interventions in novel LOAD mouse models, complemented by our cutting-edge 3D humanized cell-based microfluidic Brain-Chip platform.

Techniques associated with this Roskamp Ph.D. project include:

• Culturing and analysis of cellular and microfluidic brain-chip samples
• Tissue-specific isolation, culturing, and analysis of rodent samples
• Mutagenic and environmental risk factors on a humanized mouse platform of LOAD
• Antibody-based analytical approaches - immunoblotting, ELISA, and MSD assays
• Activity assays - metabolic measurements, oxidative stress, and antioxidant defenses
• Rodent manipulation including glymphatic, cerebrovascular, and behavioral studies
• Blood brain barrier analysis - permeability, leukocyte adhesion, waste elimination
• Cerebrovascular analysis - capillary stalling, hypoperfusion, blood flow, and reactivity
• Neuropathological and angioarchitectural analyses - microscopy, immunohistochemistry

The Roskamp Institute is a leader in the field of neuroscience, with a strong reputation for developing novel therapies for conditions such as traumatic brain injury (TBI), Alzheimer's disease and Gulf War Illness. The Institute's cutting-edge research environment offers unmatched opportunities for multidisciplinary training and hands-on experience, working with experts in translational neuroscience.

Sarasota, Florida, is known for its beautiful, pristine beaches and pleasant weather year-round, making it an ideal place to live and work. As part of the Roskamp Institute, you will not only advance your career but also enjoy the benefits of living in a vibrant coastal community.

Qualifications Required

• Master's degree in a scientific field, or a Bachelor's degree with demonstrated scientific laboratory experience.

To be considered, you must also submit an application at https://www.roskampinstitute.org/ph-d-program/