Overview A global biopharmaceutical company on a mission to Solve On Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery development and commercialization of proprietary therapeutics Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology Oncology and Inflammation and Autoimmunity Headquartered in Wilmington Delaware Incyte has operations in North America Europe and Asia. The Biotransformation group within Drug Metabolism and Bioanalysis DMB supports discovery and development programs through characterization of drug metabolism and disposition. We are seeking an experienced scientist who has the flexibility to provide hands-on lab-based support of biotransformation metabolite identification activities across a portfolio of small molecule programs. The incumbent will contribute to metabolite identification and data interpretation for compounds during optimization and development while scientifically and strategically interfacing with other DMPK colleagues as well as Medicinal Chemistry partners. Essential Functions of the Job Key responsibilities Conduct in vitro and in vivo biotransformation studies including hepatocyte microsomal and radiolabeled e.g. 14C ADME investigations Perform metabolite identification using LC-MSMS and high-resolution mass spectrometry platforms e.g. Orbitrap QTOF Analyze and interpret mass spectrometry data to characterize metabolic pathways and identify potential liabilities Serve as the biotransformation representative on assigned discovery programs with level of independence commensurate with experience Generate and communicate metabolite identification results to support medicinal chemistry and program decision-making Support development programs through analysis and reporting of preclinical and clinical ADME studies including mass balance and human ADME studies Prepare and review technical reports and contribute to regulatory documents INDNDA as appropriate Collaborate with cross-functional teams and coordinate external CRO activities as needed Qualifications Minimal acceptable level of education work experience and competency Ph.D. in Pharmaceutical Sciences Chemistry Biochemistry or a related discipline with 0-5 years of relevant industry or postdoctoral experience or M.S. with 4-8 years of relevant industry experience or B.S. with 6-10 years of relevant industry experience Experience in biotransformation and metabolite identification in a pharmaceutical or CRO environment Hands-on experience with in vitro metabolism systems e.g. hepatocytes microsomes Experience interpreting LC-MSMS or high-resolution MS data for metabolite identification Experience working with or supporting radiolabeled e.g. 14C ADME studies including sample handling data generation or interpretation Strong understanding of drug metabolism pathways e.g. CYP UGT Ability to analyze complex data and clearly communicate findings to matrix team members Preferred Qualifications Experience contributing to regulatory submissions INDNDA Familiarity with metabolite identification software e.g. UNIFI Compound Discoverer MassMetaSite Experience working in a cross-functional drug discovery environment Disclaimer The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties responsibilities and qualifications. Management reserves the right to change or modify such duties as required. Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer. We Respect Your Privacy Learn more at httpwww.incyte.comprivacy-policy The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate. During the process you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process here. You may have the right to access delete restrict edit move or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work. You can learn more about Incytes data protection practices here. By accessing this link you can learn about the types of personal data we collect how we use it whether collection and processing is optional sources of the personal data we process how it is shared where it is stored or transferred to how long we keep it and contact information for Incyte Incytes data protection officer and your supervisory authority if applicable. Please contact privacyincyte.com if you have any questions or concerns or would like to exercise your rights.