Research Laboratory Tech Sr

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How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Mission Statement

The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale.

Job Summary

Please Note: This position is a two (2) year term-limited position.

The Schneekloth laboratory at the Life Sciences Institute is looking for a research technician to join our research team. The primary research focus of the Schneekloth laboratory is the discovery and development of small molecules that modulate protein function and cellular pathways relevant to human disease. Research activities integrate medicinal chemistry, synthetic organic chemistry, pharmaceutical sciences, and chemical biology approaches to identify, characterize, and optimize novel therapeutic agents. The laboratory also employs biophysical and biochemical methods to investigate molecular interactions and mechanisms of action. You will report directly to Dr. Schneekloth and will work full-time onsite.

Responsibilities*

Experimental tasks include:

• Design, synthesize, purify, and characterize small molecules using modern synthetic organic chemistry techniques;

• Perform compound purification and characterization using HPLC, LC-MS, NMR, and related analytical methods;

• Develop and execute biochemical and biophysical assays to evaluate compound activity and target engagement;

• Perform biophysical binding studies, including Surface Plasmon Resonance (SPR), to characterize molecular interactions; and

• Analyze and interpret experimental data to support medicinal chemistry and drug discovery efforts.

Non-experimental tasks include:

• Purchase and maintain an up-to-date inventory of laboratory supplies, reagents, and equipment;

• Maintain laboratory instrumentation and organization of research spaces;

• Assist with preparation of technical reports, presentations, manuscripts, and grant-related materials;

• Maintain accurate laboratory notebooks, experimental records, and data reports;

• Work with the Principal Investigator to ensure laboratory expenditures are charged to the appropriate funding source;

• Enforce safe laboratory practices and maintain compliance with institutional safety requirements; and

• Represent the Schneekloth Laboratory at Life Sciences Institute meetings and communicate relevant information to laboratory personnel.

Required Qualifications*

• Bachelor's degree in Medicinal Chemistry, Synthetic Organic Chemistry, Pharmaceutical Sciences, Chemistry, or a closely related discipline;

• Minimum of 2 years of laboratory research experience in an academic, government, or industrial research setting;

• Minimum of one (1) year of experience performing the following techniques:

• Organic synthesis;

• Reaction optimization;

• Compound purification by chromatography;

• HPLC;

• LC-MS;

• NMR spectroscopy;

• Biochemical assays;

• Surface Plasmon Resonance (SPR);

• UV/Vis spectrophotometry; and

• Scientific data analysis and interpretation.

• Minimum of one (1) year of experience with one or more of the following software packages:

• GraphPad Prism;

• ChemDraw;

• MestReNova;

• Microsoft Office; and

• Scientific data management software.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Additional Information

Benefits at the University of Michigan

In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:

• Generous time off

• A retirement plan that provides two-for-one matching contributions with immediate vesting

• Many choices for comprehensive health insurance

• Dental, Vision and Legal insurance

• Life insurance

• Long-term disability coverage

• Flexible spending accounts for healthcare and dependent care expenses

• Maternity and parental leave

Background Screening

The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.

Application Deadline

All applications for this position must be received by 11:59p, Wednesday, September 2nd.

U-M EEO Statement

The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.