Company Overview:, Portal Biotechnologies, headquartered in Watertown, MA, is a rapidly scaling cell-engineering platform company operating across three high-value business lines (biopharma R&D screening, next-generation cell therapy manufacturing, and AI training data generation), addressing markets totaling $100B+. Since launching its first product in 2024, Portal has built a network of 100+ active customers, including the top 10 global pharmaceutical companies and leading academic hospitals and cancer centers worldwide., , Backed by $24M in venture funding and an $8M DARPA contract, Portal's proprietary mechanoporation technology enables efficient multiplex delivery of diverse cargos such as RNA, proteins, small molecules, and gene-editing tools without compromising cell function. The approach is simple and scalable, supporting applications from high-throughput drug screening to clinical-scale manufacturing, and it works both as a stand-alone system and as an integrated component in third-party platforms., , In biopharma R&D, Portal's products enable novel screening assays by delivering otherwise cell-impermeable probes and candidate molecules directly into live cells, unlocking intracellular access that standard methods cannot provide. In cell therapy, Portal's GMP-integrated consumables and a DARPA-funded portable device (launching 2027) are aimed at making engineered cell therapies as accessible and ubiquitous as an infusion pump. In AI training data, Portal generates high-value, multiparametric datasets from primary cells, producing biologically relevant training data that current cell line-based methods cannot replicate., With a leadership team bringing decades of experience in biotech operations and clinical cell therapy development, Portal is positioned to become the foundational platform for next-generation cell engineering, drug discovery, and biological AI data generation., The Role:
We are seeking an innovative and motivated scientist with a molecular biology and cell engineering background to join our team at our growing San Francisco hub. The successful candidate will contribute to research and clinical implementations of our platform across a wide range of new applications. This will include internal R&D work and partnering with external groups to drive progress across projects.. If you're someone who is excited by early-stage research, who doesn't shy away from taking on diverse responsibilities, and who thrives in a fast-paced and collaborative environment, this might just be the opportunity you have been looking for. , How you'll make an impact:, Lead individual projects to design and validate cell modification strategies, primarily leveraging mRNA and siRNA, that could enable near or long term engineering of cell function without altering the genome - various cell types including iPSCs, primary cells, and immune cells, Lead individual projects to design and validate novel intracellular detection strategies, primarily leveraging Portal's ability to deliver a wide range of impermeable probes and molecules into cells to measure intracellular target engagement and PPI, Contribute to platform development and testing for new implementations of Portal technology across research and clinical scales, Work cross-functionally with the Boston team to optimize ideal delivery strategies, Coordinate and serve as point-of-contact for studies and applications with external collaborators & clients,
| Location | Boston, MA |