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Scientist, Complex in Vitro Systems (Lung Focus)

Iconma

South San Francisco, CA

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JOB DETAILS
SKILLS
Algorithms, Analysis Skills, Assays, Bioengineering, Biology, Biotech and Pharmaceutical, Cell Analysis, Cell Biology, Communication Skills, Cross-Functional, Customer Support/Service, Data Analysis, Data Sets, Detail Oriented, Disease, Documentation, Drug Development, Drug Discovery, Establish Priorities, Experiment Design, Eye Diseases/Disorders, Health Plan, Identify Issues, Image Processing, Immunology, MATLAB, Medical Products, Medicine, Microscopy, Molecular Biology, Polymerase Chain Reaction (PCR), Problem Solving Skills, Proteomics, Publications, Pulmonary Disease, Python Programming/Scripting Language, Respiratory Medicine, Risk Analysis, Standard Operating Procedures (SOP), Team Player, Technical Support, Toxicology, Translational Research
LOCATION
South San Francisco, CA
POSTED
Today
Our client, is a Biotech company, is looking for a Scientist, Complex in Vitro Systems (Lung Focus) for their South San Francisco, CA location.
 
Responsibilities:
  • The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Scientist to develop, characterize, and qualify advanced complex in vitro models to support Client’s mission of delivering safe and efficacious medicines.
  • The CiS group partners closely with colleagues across Development Sciences, Translational Medicine, and Research to establish and implement innovative platforms that enable target assessment, lead optimization, and safety evaluation across a dynamic portfolio, novel modalities, and emerging therapeutic areas.
  • In this lab-based role, you will provide scientific and technical expertise to support the development and implementation of human lung complex in vitro models (CIVM), including lung organoids, air-liquid interface (ALI) cultures, and lung micro physiological systems for drug development.
  • Responsibilities include culturing and characterizing state-of-the-art lung CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets, and maintaining rigorous, high-quality documentation.
  • The Scientist will be expected to share scientific insights across functional teams, contribute to cross-disciplinary collaborations, and support internal and external publication efforts.
  • This position is ideal for an experienced scientist passionate about advancing disease modeling and translational safety through innovative complex in vitro.
  • The successful candidate will excel in a dynamic, collaborative research environment, demonstrate exceptional problem-solving skills, and effectively communicate across scientific disciplines to contribute to the development of cutting-edge ocular disease models and help shape the future of ocular drug discovery and development.
  • Development, qualification, and implementation of innovative in vitro lung model systems (e.g., airway and alveolar organoids, ALI cultures, lung-on-a-chip co-culture platforms) to support disease modeling and lung safety risk assessment.
  • Designing and executing experiments to characterize lung models, including evaluation of cell viability, morphology, and barrier integrity and function, using techniques such as cytotoxicity assays, confocal and high-content imaging, transepithelial resistance/permeability assays, and transcriptomic and proteomic analyses.
  • Collaborating closely with cross-functional teams within and outside gRED to align on complex model building with therapeutic strategies and program needs.
  • Analyzing, interpreting, and clearly communicating study results to collaborators and stakeholders, and contributing to internal and external scientific presentations as appropriate.
  • Maintaining comprehensive electronic documentation in accordance with departmental Standard Operating Procedures (SOPs) and contributing to study reports, safety assessments, and final deliverables.
 
Requirements:
  • PhD in Bioengineering, Cell Biology, Molecular Biology, Toxicology (or related fields) with 0-5 years of experience post-PhD with hypothesis-driven research in industry or academia.
  • Experience in culturing multiple lung cell types, including relevant lung primary cells and cell lines.
  • Proven expertise in developing, qualifying, and applying airway or alveolar organoids, co-culture systems, and micro physiological or microfluidic platforms, to support drug discovery and translational research.
  • Proficiency with quantitative and qualitative characterization techniques such as qRT-PCR, RNA-seq, proteomics, immunofluorescence and confocal microscopy, live-cell and time-lapse imaging, high-content imaging/screening, and analysis of data generated from these assays.
  • Strong experimental design skills, with demonstrated ability in troubleshooting, method development, and protocol optimization for complex in vitro systems.
  • A collaborative, team-oriented scientist who prioritizes shared objectives and communicates effectively across disciplines, with a strong work ethic grounded in scientific rigor, attention to detail, and a commitment to excellence.
  • Experience lung biology and immunology is a strong plus.
  • Advanced proficiency in MATLAB and/or Python for image processing, algorithm development, and large-scale data analysis.
 
Why Should You Apply?
  • Health Benefits
  • Referral Program
  • Excellent growth and advancement opportunities
 
ICONMA is an Equal Opportunity Employer. All qualified applicants will receive considerationfor employment without regard to any status protected by applicable law.

About the Company

I

Iconma

ICONMA is a global information consulting management firm providing Professional Staffing Services and Project-Based Solutions for organizations in a broad range of industries.

  • Corporate Headquarters in Troy, Michigan; 20+ locations worldwide.
  • Certified Woman-Owned Business Enterprise (WBE); certified by Women’s Business Enterprise National Council, National Women Business Owners Corporation (NWBOC); and California Public Utilities Commission (CPUC).
  • Founded in 2000
  • 2000+ Employees

The company was founded on the principle that success is derived from delivering high quality service and resources in the most responsive, flexible, and innovative way. ICONMA invests in people and resources with a single goal: To provide our customers with the highest quality service in the most responsive manner. Through its network of offices, ICONMA provides the resources to help clients maintain their competitive advantage.

COMPANY SIZE
2,000 to 2,499 employees
INDUSTRY
Management Consulting Services
EMPLOYEE BENEFITS
401K, Employee Referral Program, Life Insurance
FOUNDED
2000
WEBSITE
https://www.iconma.com/

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