Scientist I ADME

Scientific Responsibilities

• Design, execute, and interpret a range of in vitro ADME/DMPK studies, including:

• Metabolic stability

• Reaction phenotyping

• Metabolite identification

• CYP inhibition and induction

• Transporter studies

• Plasma protein binding

• Solubility and permeability assays

• Analyze and interpret complex scientific datasets.

• Prepare study reports, data summaries, and client presentations.

• Troubleshoot technical challenges and recommend scientifically sound solutions.

• Contribute to assay development, validation, and continuous improvement initiatives.

• Ensure studies are conducted in accordance with client requirements and applicable quality standards.

Client and Project Responsibilities

• Serve as a scientific point of contact for assigned client programs.
• Participate in project kickoff meetings, study updates, and scientific discussions with clients.
• Provide technical input during proposal development and study scoping activities.
• Support Business Development teams by participating in scientific and capabilities presentations.
• Build strong client relationships through scientific excellence and responsive communication.

Quality and Compliance

• Maintain accurate laboratory records and documentation.
• Ensure compliance with GLP, GCP, GMP, and internal quality systems as applicable.
• Support client audits, regulatory inspections, and quality investigations.
• Promote a culture of scientific integrity, quality, and continuous improvement.

Success Measures

• Deliver high-quality, scientifically robust ADME data on time.
• Build strong relationships with clients and internal stakeholders.
• Contribute to repeat business through technical expertise and exceptional customer service.
• Support growth of the ADME business through innovation, scientific leadership, and operational excellence.

Required

• M.S. with 3+ years of relevant industry experience; Pharmaceutical Sciences, Drug Metabolism, Biochemistry, Chemistry, or related field with 0-3 years of relevant experience; or
• B.S. with 5+ years of relevant industry experience.
• Experience conducting in vitro ADME or DMPK studies.
• Experience within a Contract Research Organization (CRO) environment.
• Strong understanding of drug metabolism, pharmacokinetics, and drug-drug interaction assessment.
• Experience with LC-MS/MS data interpretation.
• Excellent verbal and written communication skills.
• Demonstrated ability to manage multiple projects simultaneously.

Preferred

• Experience in metabolite identification (MetID).
• Knowledge of regulatory guidance related to DMPK studies.
• Experience supporting pharmaceutical and biotechnology clients.
• Familiarity with software such as MassHunter, Analyst, Phoenix WinNonlin, MetabolitePilot, or equivalent.
• Previous client-facing experience.
• Experience contributing to business development activities or proposal generation.

We are seeking a highly motivated ADME Scientist to join our growing Drug Metabolism and Pharmacokinetics (DMPK) team. The successful candidate will be responsible for designing, executing, interpreting, and reporting in vitro ADME studies in support of pharmaceutical and biotechnology clients. This role requires strong scientific expertise, excellent communication skills, and prior experience working in a CRO environment where client interaction, project delivery, and scientific problem-solving are critical to success.

The ideal candidate will be a collaborative scientist who enjoys working in a fast-paced, client-focused environment and is passionate about delivering high-quality data that advances drug development programs.