Scientist I-Ii, Analytical Development

Who We Are

Antheia is the advanced biosynthesis company transforming pharmaceutical manufacturing and innovation for the 21st century. Antheia's commercially proven technology platform produces high-value pharmaceutical ingredients in a fraction of the time compared to legacy approaches while significantly reducing supply chain risk. The company provides its global pharmaceutical customers with a resilient, efficient supply of critical ingredients at scale, while expanding the innovation frontier for new therapeutic development. Backed by leading investors and recognized by the U.S. government as a priority technology for public health and national and economic security, Antheia is manufacturing the medicines the world needs today while enabling tomorrow's breakthrough therapeutics.

As a key member of Analytical Development group, you will be responsible for working closely with biology and fermentation teams to develop, implement and support analytical solutions to guide metabolic engineering and scale-up process by evaluation of metabolites from engineered yeast strains in microtiter plates up to multi-L tank scale. This includes refining and executing analytical operations to handle large sample numbers in timely manner, as well as developing specialized methods across HPLC, UPLC, LC-MS, and GC-MS instruments. A successful candidate will be very organized and detail-oriented, self-driven and possess leadership qualities to deliver high value solutions and processes in fast-paced environment.

Responsibilities

• Perform analytical method development and optimization for quantification of small molecules using UPLC-UV, LC-MS and GC-MS instruments from sample preparation to data analysis and interpretation

Collaborate with scientists in biology and fermentation to understand analytical needs, deliver feedback on feasibility, timelines, and resource requirements of their requests, and deliver maximum value by developing appropriate method and process in house or outsourcing to external laboratories.

• Manage, coach, and mentor a small team of Analytical Chemists, direct daily work and task, conduct performance evaluations, set goals, and provide constructive feedback.
• Develop and implement processes to quickly and unambiguously address issues with unexpected analytical results, timely troubleshoot and resolve analytical method related errors and give feedback to biology and fermentation teams.
• Be a subject matter expert for all routine in-house assays, train and guide junior staff in execution of those assays to defined specs in a timely manner.
• Prioritize work of junior staff between routine analytical operation and method development and optimization activities to minimize sample backlog and achieve development goals, give feedback to senior management if there are resource constraints and collaborate on finding solutions.
• Perform maintenance and troubleshoot common instrumentation failures and errors.
• Prepare samples for routine analysis including instrument setup and data analysis
• Prepare technical reports/SOPs and clearly communicate scientific findings.
• Adhere to safe laboratory practices.
• Perform other duties as assigned

Qualifications

• B.S. with 10+ years of experience or Ph.D. with 2+ years of experience in Analytical Chemistry or related field.
• Experience with UPLC/UV, LC/MS/MS and GC/MS on fermentation-derived matrices required.
• Proven track record of successful method development and qualification.
• Theoretical knowledge of diverse analytical techniques.
• Motivation and ability to solve complex analytical problems and build effective processes in a startup environment.
• Experience managing direct reports with proven ability to delegate tasks, motivate staff, and make balanced operational decisions under pressure
• Experience of collaborative work across multiple teams, building trust, fulfilling requests, giving constructive feedback, resolve conflicts and meeting timelines.
• Experience working with Agilent software.
• Experience with Agilent Bravo liquid handling automation and Agilent RapidFire is a plus.

Compensation

Full-time base salary range of $120,000 - $155,000 annually plus an annual bonus potential and equity opportunities.

Must be legally authorized to work in the United States on a permanent basis. Antheia is not providing visa sponsorship for this role.