Scientist I, Single-Cell Genomics

Scientist I, Single-Cell Genomics

The goal of Allen Institute for Cell Science is to develop a comprehensive approach to measure, describe, and model cell states and their dynamic changes over time with the ultimate goal of uncovering the fundamental principles of multiscale, multicellular morphogenesis, including how groups of cells organize and achieve collective behaviors essential for life. Our approach encompasses multi-modal data collection including live 3D timelapse imaging, data analysis, theory, and predictions to understand cell states and cell state transitions in human induced pluripotent stem cell models. As a division within the Allen Institute, the Allen Institute for Cell Science uses a team-oriented approach, focusing on accelerating foundational research, developing standards and models, and cultivating new ideas to make a transformational impact on science.

The Allen Institute for Cell Science seeks a collaborative Scientist I to support computational analysis of single-cell RNA-seq datasets in projects focused on cell-state transitions during tissue morphogenesis in human iPSC-derived 3D culture systems. This role is well suited to a scientist with strong biological grounding, quantitative skills, and an interest in using data analysis to generate clear biological insight.

The Scientist I will primarily analyze single-cell RNA-seq datasets, develop reproducible workflows and visualizations, and collaborate closely with experimental and computational colleagues to support biological discovery in human iPSC-derived 3D culture systems.

We believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Please submit a resume and cover letter to be considered for this role.

Essential functions

• Perform analysis of single-cell RNA-seq datasets to characterize cell states, state transitions, and biological heterogeneity in human iPSC-derived 3D culture systems
• Develop reproducible analysis workflows, code, and visualizations using sound data-analysis practices
• Build and maintain R Shiny applications and related outputs to support data exploration and internal scientific decision-making
• Collaborate with experimental and computational colleagues to interpret biological findings from data and align analysis plans with project goals, sample design, and metadata needs
• Support data organization, documentation, and version control to enable effective collaboration and reuse
• Stay current with methods and literature in single-cell genomics
• Communicate findings clearly through presentations, figures, documentation, and manuscript contributions

Required Education and Experience

• PhD in cell biology, developmental biology, stem cell biology, computational biology, bioengineering, biophysics, or a related field, or equivalent combination of education and experience
• Experience analyzing single-cell RNA-seq datasets
• Proficiency in R and/or Python for biological data analysis
• Experience developing reproducible analysis workflows and clear data visualizations

Preferred Education & Experience

• Proficiency in Linux-based computing environments and version control tools such as Git
• Ability to build interactive data-exploration applications, such as R Shiny apps
• Background in developmental biology, stem cell biology, morphogenesis, or cell-state transitions
• Experience working with iPSC-derived model systems or 3D cell culture systems
• Understanding of wet-lab assay design considerations and practical limitations of single-cell or spatial experiments
• Knowledge of spatial biology approaches, including spatial transcriptomics and/or multiplexed protein imaging
• Ability to work effectively on interdisciplinary projects with experimental and computational collaborators
• Strong organizational, written, and verbal communication skills
• Publication record demonstrating contribution to single-cell or related biological data analysis

Physical Demands

• Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with equipment.

Position Type/Expected Hours of Work

• This role is currently able to work both remotely and onsite in a hybrid work environment, with the expectation to work 3 days onsite. The primary work location for this role is 700 Dexter Ave N.

Annualized Salary Range

• $86,150 - $106,650*

* Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable.

Benefits

Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute’s Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute’s 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institute’s benefits offering are located at the following link to the Benefits Guide: https://alleninstitute.org/careers/benefits.

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities