Scientist I

Description: Working Model: onsite (five days a week)

Working days: Monday through Friday

Working hours (e.g. 8 AM to 4 PM PT, 9 AM to 5 PM, etc.): Standard 8 hours

Interview Format (e.g. 1-2 rounds of virtual interviews)

Position Summary
We are seeking a highly motivated and skilled Scientist to join our Biochemical and Cellular Pharmacology Department. This hands-on, laboratory-based role focuses on the development and execution of induced proximity-based assays crucial for the discovery and validation of novel therapeutic compounds. The successful candidate will work at the heart of a multi-disciplinary environment, translating experimental data into actionable insights for our drug discovery programs.
In this role, the candidate will have the unique opportunity to pioneer new induced-proximity approaches and help shape the scientific direction of early-stage drug-discovery programs.

Key Responsibilities

• Assay Development: Design and develop biochemical and cell-based assays for quantitative measurement of protein-protein and protein-small molecule interactions.

• Screening & Validation: Conduct routine screening and deep-dive validation studies to support lead identification and optimization.

• Data Analysis: Perform rigorous analysis of complex data sets, ensuring high quality and reproducibility.

• Cross-Functional Collaboration: Partner effectively with colleagues in Pharmacology, Protein Science, Medicinal Chemistry and Research Biology.

• Communication: Prepare technical reports and present findings clearly during multi-disciplinary project team meetings.

Education & Experience

• Degree: B.S. or M.S. in Biochemistry, Biophysics, Cellular/Molecular Biology, or a related scientific discipline.

• Experience: 1-3 years of hands-on laboratory experience within an academic, biotechnology, or pharmaceutical industry setting.

Mandatory Skiils Requirements

• Demonstrated experience designing, developing, validating, and executing cellular and biochemical assays, supported by a strong theoretical and practical understanding of biochemistry and biophysics relevant to complex protein systems.

• Direct experience with induced proximity assays and modalities (molecular glues, bivalent degraders, ternary complexes and multicomponent binding systems).

• Proficiency with data analysis methods and specialized software. Ability to move beyond default vendor fits and analyze complex system behavior using Prism, Python, R or comparable tools.

• Proven ability to critically analyze and interpret complex data sets, troubleshoot experimental hurdles, and a proactive interest in adopting new technologies.

Preferred Technical Skills (Advantageous)

• Experience with protein biochemistry, recombinant protein expression and molecular biology methods (e.g. western blot, cell culture, cell growth assays).

• Experience with nanoBRET, nanoBiT, TR-FRET, BRET as well as imaging-based approaches.

• Familiarity with automated or semi-automated laboratory instrumentation (e.g., liquid handlers, plate washers).

• Ability to thrive in a fast-paced, dynamic environment and remain productive through shifting priorities or project changes.

• Proven ability to work effectively as part of a high-functioning, multi-disciplinary team.

• A proactive approach to troubleshooting and a keen interest in learning new technologies as project needs evolve.

Skills: