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Scientist-II

Integrated Resources, Inc

Lower Gwynedd Township, Pennsylvania

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JOB DETAILS
JOB TYPE
Contractor
SKILLS
Assays, Banking Services, Biochemistry, Biomedical Engineering, Business Strategy, Cell Biology, Cell Cultures, Chemistry, Clinical Research, GMP (Good Manufacturing Practices), Information Technology & Information Systems, Laboratory Notebook, Manufacturing, Manufacturing Analysis, Manufacturing Technology, Molecular Biology, Organizational Skills, Real-time PCR (qPCR), Rehabilitation Nursing, Research Contracts, Reverse Transcriptase PCR (RT-PCR), Scalable System Development, Scientific Research, Stability Analysis, Systems Analysis, Technical Support
LOCATION
Lower Gwynedd Township, Pennsylvania
POSTED
Today
Scientist-IIIntegrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.Job DescriptionDuration: 6 Months + ContractThe candidate will contribute to the evaluation and development of scalable AAV manufacturing technologies in support of efforts to develop human therapies. She/he will work to engineer a mammalian expression host as well as to help evaluate alternative expression systems such as baculovirus. The scientist will work to develop cell lines that be used in GMP manufacturing of AAV-based therapies.ESSENTIAL FUNCTIONS:The candidate will work to engineer a mammalian expression host for large-scale AAV production. This entails development of stable mammalian cell lines including transfection, selection, clone screening and cell banking. Screening will include assessment of transgene stability and AAV production upon scale-up and induction.Strong molecular biology and cell culture experience is essential. Small scale AAV production and characterization in mammalian cell culture or Baculovirus systems for the assessment of manufacturing systems and/ or to support target validation activities is highly desirable.Experience developing and characterizing stable mammalian cell lines is required. The candidate should have experience performing routine quantitative assays including qPCR, RT-PCR, Western Blot, ELISA and others.The ability to generate and maintain experimental data in an electronic laboratory notebook in a highly organized manner is essential.PRINCIPAL RELATIONSHIPS:Contacts inside the Company:Leaders and scientists in Biologics Research, Centyrex, BCoE, and Therapeutic Areas,Contacts outside the Company:Strategic external business partners, academic institutions, key opinion leaders, and contract research organizationsSupervision required:MinimalQualificationsEducation: M.S. in Biomedical Engineering, Molecular Biology, Cell biology, Biochemistry, Chemistry or a related field with 2+ years industry experience.Significant Safety or Working Considerations: N/A

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Integrated Resources, Inc

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