Scientist II

Scientist II

Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.

Job Description

The Tumor Cell Biology Department of the Oncology-Rinat Research division in La Jolla, CA is seeking a full time contractor to join our drug discovery team.

The scientist/biochemist will make important contributions to the discovery and pre-clinical development of oncology therapeutics.

In particular, the biochemist will be responsible for the development and validation of robust, reproducible plate-based enzyme assays.

This will include kinetic and mechanistic studies to characterize enzyme targets, biochemical pathways, and mechanism of action of lead compounds.

This may also include development of assays which measure ligand-receptor interaction using purified proteins, membrane preparations or cells.

Candidate will be responsible for testing lead compounds in biochemical and cellular assays, data analysis, and proper database publication of data.

Candidate will participate on project teams, providing insight and technical expertise required for project progression.

Qualifications

BS or BS/MS with 2-5 years or more experience in industry or relevant academic lab.

Candidate will have extensive experience in biochemical and cellular assay development and validation.

Experience in cancer research, drug discovery, immunology, or cross discipline skills which can be applied to drug discovery.

Knowledge of biochemistry theory and practice, with particular understanding of enzymology.

Experience in assay development, mechanisms of enzyme inhibition, and assays which measure ligand receptor interaction is preferred.

Experience with automation of assays, LC-MS, radio-labeled ligand binding, fluorescence, and coupled-enzyme assays is also desired.

Experience with standard Windows 7/8, Microsoft Office including Excel, and GraphPad Prism.

Candidate must be able to quickly learn new in-house software for data management.

Must have strong oral and written communication skills.

Must be competent in standard chemical calculations to accurately prepare laboratory solutions and calculate dilutions for screening.

The candidate must be flexible, organized and attentive to details.

Accurate record keeping and ability to follow precise steps in a protocol are required.

Ability to multi-task, able to independently analyze data, troubleshoot and solve problems.

Ability to work independently and contribute to team goals in a collaborative environment.

Preference for candidates with pharmaceutical/biotech drug discovery experience evaluating small-molecule inhibitors of enzyme or receptor targets.

Physical and Mental requirements-

Work at lab bench and at desk.

Work with standard radioactive materials (3H, 32P, etc.)

Ability to process and analyze raw data using software programs including Excel, GraphPad Prism and Activity Base.

Must maintain an electronic lab notebook and keep records up to date.