Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
The Scientist II / Senior Scientist, ADME will contribute to the design and execution of nonclinical pharmacokinetics/PKPD/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, Head of ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs.
Responsibilities
- Perform modeling and simulation, analyze PKPD and PK/TK data, and provide clear interpretation to inform program decisions.
- Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions.
- Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines.
- Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME.
- Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively.
- Maintain awareness of evolving best practices and regulatory expectations in ADME sciences.
Qualifications
- PhD in a relevant discipline with 0–3 years of industry experience in ADC PKPD and ADME, or MS with 5+ years relevant industry experience.
- Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred.
- Hands-on expertise in PKPD modeling, PK/TK analysis, and study design.
- Knowledge of both non-regulated and regulated bioanalysis.
Knowledge and Skills
- Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment.
- Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences.
- Collaborative approach with the ability to work across disciplines to achieve program goals.
Level and compensation will be commensurate with relevant experience.
Washington State Pay Range
$149,930 - $203,961USD