Scientist III – Cell Biology & Molecular Biology

Location: Ridgefield, CT
Duration: 12 Months
Company: Sigma Systems
Job Type: Contract

Job Overview

Sigma Systems is seeking an experienced Scientist III to support scientific research and drug discovery activities in Ridgefield, Connecticut. This role is ideal for a non-PhD scientist with a strong background in mammalian cell culture, molecular biology, cell-based assays, and biochemical techniques within a pharmaceutical, biotechnology, or contract research organization (CRO) environment.

The successful candidate will independently design and execute in vitro experiments, analyze and interpret scientific data, troubleshoot experimental challenges, and contribute to research initiatives in a highly collaborative laboratory environment.

Weekend Commitment: Approximately 2–4 hours each weekend to support business operations. Scheduling is flexible and can typically be completed at a time that works best for the employee.

Key Responsibilities

• Independently initiate, design, and execute routine in vitro studies and cell-based experiments in a timely and efficient manner.

• Analyze experimental results, interpret scientific data, troubleshoot issues, and recommend appropriate follow-up experiments.

• Design and perform non-routine cell-based and biochemical assays using scientific literature, published protocols, and established research methods.

• Perform mammalian cell culture and aseptic laboratory techniques while maintaining consistent experimental quality.

• Execute molecular biology procedures, including nucleic acid extraction, RT-PCR, Western blotting, ELISA, and transfection.

• Conduct literature searches to identify relevant scientific information, evaluate emerging technologies, and support research innovation.

• Operate, maintain, and troubleshoot laboratory instruments and equipment independently.

• Develop experimental approaches that support drug discovery and development objectives.

• Maintain accurate electronic laboratory notebooks, experimental records, and research documentation.

• Prepare and contribute to technical reports, scientific reports, laboratory protocols, and standard operating procedures (SOPs).

• Communicate experimental findings clearly and accurately to research teams and department leadership.

• Support the training and development of laboratory technicians and junior scientists.

• Maintain data integrity and comply with applicable laboratory safety requirements, regulations, and established procedures.

Required Qualifications

• Master’s degree with at least 3 years of relevant experience, or Bachelor’s degree with at least 7 years of relevant experience, or equivalent experience in a related scientific discipline.

• Non-PhD candidate required.

• Experience in pharmaceutical, biotechnology, or CRO environments is highly desirable.

• Hands-on experience with aseptic mammalian cell culture and in vitro experimental techniques.

• Strong working knowledge of basic molecular biology techniques, including:

  • Nucleic acid extraction

  • RT-PCR

  • Western blot

  • ELISA

  • Transfection

• Ability to independently operate laboratory equipment and troubleshoot experimental procedures.

• Experience designing experiments, executing protocols, interpreting results, and reporting technical data.

• Proficiency in Microsoft Excel and scientific data analysis software such as GraphPad Prism.

• Strong written and verbal communication skills.

• Demonstrated problem-solving skills, scientific judgment, and attention to detail.

• Understanding of laboratory safety, applicable regulations, and documentation requirements.

• Ability to work independently while contributing effectively to a collaborative research team.

Preferred Qualifications

• Experience with human pluripotent stem cell culture.

• Supplemental technical training in cell biology, molecular biology, or a related scientific discipline.

• Experience evaluating new laboratory technologies and supporting their implementation.

• Previous experience mentoring technicians or junior-level scientists.

• Familiarity with electronic laboratory notebooks, SOPs, and scientific documentation practices.