Scientist - Off-Target Genomics (Gene Therapy)

At Eurofins Professional Scientific Services (PSS), the work we do matters-and so do our employees. We are committed to supporting your professional growth by providing opportunities to enter and advance within the biopharmaceutical industry. Our teams are collaborative and supportive, offering the tools and environment needed to succeed while maintaining work-life balance and a competitive benefits package.

Eurofins Scientific is a global leader in life sciences, delivering a broad range of analytical testing services across industries including pharmaceuticals, food, environmental, and clinical research. Our work helps ensure product safety, quality, and compliance, contributing to a healthier and more sustainable world.

We are seeking a Scientist - Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects, genomic integrity, and emerging genome editing modalities.

Key Responsibilities:

• Lead genomic safety assessment packages, including off-target discovery, verification, validation, and genomic integrity characterization

• Apply and evaluate off-target discovery approaches using:

• In silico tools (e.g., CALITAS, CRISPRme, Cas-OFFinder)

• Biochemical methods (e.g., SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq)

• Cell-based assays (e.g., GUIDE-seq, INDUCE-seq)

• Drive off-target confirmation using sequencing-based approaches such as AmpSeq, rhAmpSeq, and hybrid capture

• Assess genomic integrity using orthogonal platforms including karyotyping, optical genome mapping, and whole genome sequencing (WGS)

• Evaluate genotoxicity risks associated with next-generation genome editing technologies, including base and prime editing

• Support and/or lead development of novel assays for emerging genome editing modalities (Gen 5+)

• Integrate biodistribution data to inform tissue selection for off-target verification studies

• Collaborate cross-functionally and present findings clearly to scientific and project teams

Minimum Qualifications:

• B.S. with 5+ years, M.S. with 3-7 years, or Ph.D. with 2-4 years of industry experience in genomics, molecular biology, biochemistry, or a related field
• Hands-on experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics
• Strong working knowledge of CRISPR-based genome editing technologies
• Experience with next-generation sequencing workflows and data interpretation
• Familiarity with base editing, prime editing, and associated genotoxicity considerations
• Demonstrated scientific problem-solving skills; assay development experience is a plus
• Strong communication skills with the ability to present complex data to diverse audiences
• Self-motivated, adaptable, and able to work both independently and collaboratively

Preferred Qualifications:

• Experience with optical genome mapping (e.g., Bionano platform)
• Understanding of regulatory expectations for genomic safety (IND/BLA submissions)
• Exposure to human diversity-informed off-target methods (e.g., ONE-seq)
• Authorization to work in the U.S. without sponsorship

The position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to apply

What to Expect in the Hiring Process:

• 10-15 Minute Phone Interview with Regional Recruiter
• 45-60 Minute Virtual Interview with Manager and/or Group Leader
• 45-60 Minute In-Person Meeting for a Casual Discussion of the Role

What We Offer:

• Excellent full-time benefits, including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Yearly goal-based bonus & eligibility for merit-based increases
• Annual Compensation is $104,000 - $112,320, depending on education and experience

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.