Location Memphis TN Category Laboratory Sciences & Support Department Cell and Molecular Biology Shift Weekday Day Position Type Full Time Scheduled Weekly Hours 40 Req JR6129
Job Description
We are seeking a highly motivated and talented scientist to join our team and lead cutting-edge research exploring the therapeutic potential of intrinsically disordered regions. This project will harness pooled lentiviral screening platforms for baseprime editing mutagenesis to systematically perturb key molecular interactions. It offers an exciting opportunity to apply innovative high-throughput technologies to uncover new regulatory mechanisms and identify novel therapeutic targets. The successful candidate will play a central role in developing and implementing advanced lentiviral-based screening pipelines across diverse biological systems working at the interface of molecular biology genomics and translational discovery.
The Worlds Brightest Minds Always Innovate
At St. Jude Childrens Research Hospital we know what can be achieved when the brightest scientific minds face the fewest barriers. Thats why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative bench-to-bedside environment where you can see firsthand how your science translates into survival for the children we serve. Quite simply at St. Jude we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.
Key Responsibilities
Design optimize and execute pooled lentiviral screening workflows for large-scale baseprime editing mutagenesis. Collaborate closely with bioinformaticians and project investigators to ensure robust experimental design data acquisition and analysis. Drive the development of innovative experimental strategies to expand and enhance existing screening capabilities. Contribute to collaborative research outputs including publications and conference presentations.
Ideal Candidate
PhD or equivalent experience in Molecular Biology Cell Biology Genetics or a closely related field. Demonstrated expertise in the design production and application of lentiviral vectors for genetic manipulation and screening. Proven track record in developing implementing or applying high-throughput genetic perturbation or functional screening approaches. Excellent organisational communication and record-keeping skills. Strong problem-solving ability and capacity to work independently as well as collaboratively. Desirable Attributes
Extensive experience in CRISPR-based genome engineering in mammalian cell systems. Demonstrated expertise in the design production and application of lentiviral libraries for large-scale screening. Experience with base or prime editing systems. Familiarity with large-scale data generation and interpretation in screening contexts. Evidence of contributions to collaborative research initiatives or consortia.
About the Research Environment
The Davey lab has recently joined the Department of Cell and Molecular Biology to launch a research program applying high-throughput screening approaches to uncover the therapeutic potential of intrinsically disordered regions. The post-holder will work within a collaborative supportive team and benefit from world-class core facilities and excellent opportunities for professional development.
What problem are we tackling
Target discovery is a critical foundation of drug development underpinning efforts to overcome the persistent challenges of drug resistance emerging pathogens and complex diseases that lack effective therapies. By uncovering novel proteins and molecular pathways driving disease progression we can enable the rational design of more selective interventions that reduce off-target effects and improve patient outcomes. The development of tool molecules coupled with detailed characterisation of their inhibitory mechanisms provides a direct bridge between phenotypic observations and small-molecule drug design accelerating the translation of basic discoveries into clinically actionable therapies.
What is our approach
Short Linear Motifs SLiMs are compact functional modules embedded within the intrinsically disordered regions of proteins. They mediate a wide range of regulatory processes including the assembly of dynamic complexes recruitment of modifying enzymes control of protein stability and specification of subcellular localisation. Despite their central role in cellular regulation SLiM-binding pockets remain a largely untapped class of therapeutic targets. By applying large scale base-editing and peptide inhibitor studies the project will address three key questions i How essential are SLiM-mediated interactions for cellular fitness ii Does SLiM essentiality differ between healthy and diseased cells iii Can these interactions be selectively targeted for therapeutic intervention
Minimum Education andor Training
Bachelors degree in relevant scientific area is required. Minimum Experience Eight 8 years of relevant work experience is required with a Bachelors degree. Six 6 years of relevant work experience is required with a Masters degree. Three 3 years of relevant work experience is required with a PhD.
Better at Work. Better at Life
When you work at St. Jude youll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and youll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a Best Place to Work.
Benefits
Your health and well-being are important to us. Thats why St. Jude Childrens Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents.
View all the benefits offered including Medical & Prescription Drug Plans Dental Plan Vision Plan Financial Security Retirement Plan Living Well - Employee Wellness Program Time Off Programs Educational Benefits Family Friendly Benefits and Benefits Unique to St. Jude.
Have More in Memphis
Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20 lower than the national average and our state places no personal income tax on wages. Plus Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can Have More in Memphis.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is 86,320 - 154,960 per year for the role of Scientist Pooled Lentiviral Base Editing Screening.
Explore our exceptional benefits
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Shared Resources
Innovation St. Jude Cloud Benefits and Perks Life in Memphis