Primary Talent Partners has a new contract opening for a Scientist, Translation Biology to join our pharmaceutical client in Cambridge, MA. This is a 12-month contract to start with the potential for extensions.
Pay:$63.00 - $73.00/hr; W2 contract, no PTO, no Benefits. ACA-compliant supplemental package available for enrollment. Candidates must be legally authorized to work in the United States and must be able to sit on Primary Talent Partners W2 without sponsorship.
Schedule: 100% Onsite
Description:
This is a contract position supporting the discovery and development of in vivo CAR-T cell therapies for autoimmune indications and other malignancies within the Immunology & Translational Biology Research organization.
This individual will design and execute a broad range of in vivo and ex vivo experimental workflows, interpret results to determine next steps, maintain rigorous digital and physical records, and contribute scientific judgment to the continuous improvement of assays and protocols.
The successful candidate will be a technically skilled, highly organized, and intellectually curious scientist who can operate independently on complex problems while collaborating effectively across cross-functional teams – balancing rigorous protocol adherence with sound scientific judgment and proactive cross-functional collaboration.
Key Responsibilities:
In Vivo & Ex Vivo Studies: Execute mouse studies supporting in vivo CAR-T programs, including organ harvest, tissue dissociation, and downstream processing of mouse organs, cell line maintenance, human PBMCs, and NHP samples.
Flow Cytometry: Design, optimize, and execute multiparameter (10+ color) flow cytometry panels for immunophenotyping and functional readouts; perform data analysis using FlowJo and present findings to project teams and cross-functional stakeholders.
LNP Transfection: Design and perform lipid nanoparticle (LNP)-mediated transfection experiments to support in vivo delivery platform development; evaluate potency of formulated tLNPs using cell-based assays and propose protocol refinements
T & PBMC Cell Culture: Maintain and activate primary human T and PBMC cell cultures; design co-culture systems and functional assays to assess lymphocyte biology and targeted killing efficacy against specific targets.
Functional Assays: Execute flow cytometry-based and Incucyte live-cell imaging functional assays to assess cell health, proliferation, cytotoxicity, and engagement.
Digital Record-Keeping & Benchling: Maintain complete, contemporaneous, accurate, and audit-ready experimental records in Benchling, including ELNs, protocols, results, and reagent inventory.
Protocol Adherence & Scientific Judgment: Follow established SOPs with strict attention to detail while proactively identifying discrepancies, deviations, or opportunities for optimization and escalating or resolving them appropriately.
Cross-Functional Collaboration: Interface with partner teams (e.g., CMC) to coordinate experiments, share data, and provide technical support including hands-on training for flow cytometry or assay execution.
Logistics & Planning: Manage scheduling of complex multi-step experiments, reagent ordering, biosample coordination, and equipment bookings to ensure uninterrupted research operations.
Team Structure – how does this role fit with the team
Reports to: Senior Scientist, Immunology & Translational Biology
Key External Interfaces: CRO/vendor coordination as needed
Role in Team The EG-100 Scientist operates under limited supervision, designing and executing the next logical step. In a series of related experiments while demonstrating independence on complex, sometimes ambiguous problems.
This individual is expected to:
Deliver high-quality data with consistency and reproducibility, based on interpretation of prior results
Develop new or alternative protocols and troubleshoot routine problems independently
Make decisions that impact the entire work group/project team, choosing between multiple options to resolve complex problems
Manage their own experimental schedule with logistical competence
Flag discrepancies and propose solutions, rather than simply executing tasks
Act as a technical point of contact and functional mentor within the work group
Contribute meaningfully to cross-functional activities, presentations, and team documentation
This is not a purely task-execution role—scientific curiosity, proactive communication, and a drive for continuous improvement are core expectations at this level, along with an increasing mentorship and technical-leadership footprint.
Must-have Qualifications:
B.S. with 5+ years, M.S. with 3+ years of academic/industry experience in Biology, Biochemistry, Immunology, or a closely related life science discipline
Ability to work on-site under a contract engagement, 1-year duration (subject to extension/renewal per business need)
Demonstrated expertise in multiparameter flow cytometry (panel design, execution, and analysis via FlowJo), with a track record of designing new experimental approaches
Experience with functional assays (flow-based or live-cell imaging platforms such as Incucyte)
Experience with ex vivo tissue processing from mouse organs, human PBMCs, and/or NHP samples
Experience with LNP and electroporation-based transfection methods
Experience with primary T and PBMC cell culture, activation, and viability assessment as well as cell line maintenance
Proficiency in Benchling (ELN, protocols, inventory management)
Demonstrated ability to maintain meticulous records and follow complex multi-step protocols
Demonstrated ability to troubleshoot routine problems independently, and propose new or alternative protocols
Proven organizational and planning skills, with the ability to manage multiple concurrent experiments and act as a technical point of contact within the work group
Nice-to-have Qualifications:
Experience in autoimmune and oncology disease models or CAR-T cell biology
Familiarity with IND-enabling study workflows or GLP-adjacent environments
Organizational Excellence: Demonstrates proactive scheduling, supply management, and logistical coordination to keep complex, multi-step in vivo / ex vivo programs running without interruption. Anticipates downstream needs (e.g., reagent lead times, instrument availability, biosample scheduling) and coordinates across multiple concurrent experiments.
Attention to Detail: Documents all experimental steps completely in Benchling in real time and ensures data integrity from bench to analysis. Flags inconsistencies in reagent lots, instrument performance, or protocol deviations immediately.
Scientific Judgment & Independent Thinking: Designs the next logical step in a series of experiments based on interpretation of prior results; develops new or alternative protocols rather than simply following established ones; resolves complex problems by choosing between multiple options.
Technical Leadership & Mentorship: Acts as a functional mentor to junior team members; may act as a technical point of contact for the work group; makes presentations in small, multidisciplinary meetings to convey clear, key messages.
Collaboration & Communication: Interfaces comfortably with partner functions, explains issues and builds alignment around complex situations, and adapts communication style for the audience.
Additional Standout Experience
Experience:
Required Experience 3+ years with M.S.; 5+ years with B.S.
Preferred Experience 3+ years with M.S
Overqualified Indicators / Similar Titles PhD
Target Companies
Education & Certifications:
Education Required B.S.
Education Preferred M.S.
Primary Talent Partners is an Equal Opportunity / Affirmative Action employer committed to diversity in the workplace. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, age, national origin, disability, protected veteran status, gender identity, or any other factor protected by applicable federal, state, or local laws.
If you are a person with a disability needing assistance with the application or at any point in the hiring process, please contact us at info@primarytalentpartners.com
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Numbers & Facts
Location
Cambridge, MA
Salary
$63–$73 Per Hour
Skills
Analysis Skillsunmatched
Assaysunmatched
Autoimmune Diseaseunmatched
Biochemistryunmatched
Biologyunmatched
Biotech and Pharmaceuticalunmatched
Calendar Managementunmatched
Cell Biologyunmatched
Cell Culturesunmatched
Communication Skillsunmatched
Continuous Improvementunmatched
Contract Research Organization (CRO)unmatched
Cross-Functionalunmatched
Data Analysisunmatched
Data Entryunmatched
Data Qualityunmatched
Data Visualizationunmatched
Detail Orientedunmatched
Documentationunmatched
Experiment Designunmatched
Functional Analysisunmatched
GLP (Good Laboratory Practices)unmatched
Identify Issuesunmatched
Immunologyunmatched
Inventory Managementunmatched
Leadershipunmatched
Logisticsunmatched
Mentoringunmatched
Microscopyunmatched
Oncologyunmatched
Operations Researchunmatched
Organizational Skillsunmatched
Patentsunmatched
Prismunmatched
Problem Solving Skillsunmatched
Process Improvementunmatched
Publicationsunmatched
Record Keepingunmatched
Regulationsunmatched
Schedule Developmentunmatched
Standard Operating Procedures (SOP)unmatched
Team Lead/Managerunmatched
Technical Leadershipunmatched
Technical Supportunmatched
Technical Writingunmatched
Translational Researchunmatched
Vendor/Supplier Managementunmatched
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