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SD_Scientist I

Compass Consulting

San Diego, CA

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JOB DETAILS
SKILLS
Analysis Software, Analytical Development, Antibodies, Assay Development, Biotech and Pharmaceutical, Chemistry, Communication Skills, Cross-Functional, Detail Oriented, Gene Therapy, Laboratory Notebook, Medical Conditions, Medical Products, Medical Treatment, Microscopy, Microsoft Excel, Nanotechnology, Polymers, Presentation/Verbal Skills, Prism, Process Improvement, Sales Pipeline, Small Molecules, Standard Operating Procedures (SOP), Writing Skills
LOCATION
San Diego, CA
POSTED
30+ days ago
Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

Role Overview:

We seek an outstanding candidate to join the Gene Therapy Nanotechnology team. The Scientist I will contribute to our cutting-edge delivery platform by designing, preparing, and characterizing ligand conjugates and targeted lipid nanoparticles. A critical component of this role is supporting targeted delivery systems through bioconjugation chemistry, including preparing protein conjugates and formulating targeted LNPs. Responsibilities include executing bioconjugations (e.g., antibodies, peptides) with small molecules or polymers; validating and purifying bioconjugates via LC-TOF and ÄKTA purification station; formulating non-targeted and targeted LNPs encapsulating nucleic acids using microfluidic or T-junction mixing technologies; performing surface bioconjugation for targeted LNPs; supporting analytical assay development (BLI, fluorescence microscopy, ÄKTA); evaluating ligand and particle stability under various conditions; maintaining electronic laboratory notebooks; and authoring SOPs.

Skills:
  • Extensive hands-on experience in bioconjugation methodologies, process optimization, and bimolecular reaction kinetics.
  • Prior expertise in Antibody-Drug Conjugate (ADC) development is strongly preferred.
  • Proven experience with lipid nanoparticle formulation and LNP characterizations via RiboGreen, Dynamic Light Scattering (DLS), and Zeta potential measurement.
  • Proficiency in bioconjugation and formulating buffers is required.
  • Excellent attention to detail and ability to produce consistent results and effectively communicate with cross-functional teams.
  • Proficiency in MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable.
  • Excellent oral and written communication skills.

About the Company

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Compass Consulting

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