Senior Associate Scientist, In Vivo Pharmacology,  Oncology

About Perceptive

Our mission is to shape the future of clinical research. With decades of experience and the brightest minds in the industry, we help the global biopharmaceutical industry bring new, advanced medical treatments to market, faster.

We seek to change the world, and with the support of our teams across the globe, we flourish together. At Perceptive, we are one team. We learn, grow and win together.

Are you ready to help change the world?

Apart from job satisfaction, we can offer you:

HEALTH:

• Medical, Dental and Vision benefits for you and your family, including Flexible Spending Accounts (FSA) and Health Savings Accounts (HSAs)

YOURSELF:

• Paid time off policy including holidays and sick time
• Internal growth and development programs & trainings

WEALTH:

401(k) program, life & accident insurance and disability insurance

About the role

We are seeking a motivated and skilled Senior Associate Scientist to support validation and execution of our imaging studies using preclinical in vivo oncology- models. This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging. The successful candidate will also provide technical support across a range of in vivo studies including efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry and ex vivo analysis of target tissues of relevance in oncology, xenograft models.

Key Responsibilities

Essential Functions:

Aid in the management of the Animal Care Facility (ACF)

• Ordering of animals and supplies

• Sanitization and equipment maintenance

Follow, execute and write laboratory specific SOP's related to role

Assess study protocols for experimental details

• Participate in protocol reviews

• Lead projects and schedule necessary In-Vivo tasks

• Meet and determine timelines related to protocol execution

Assess animal health conditions, communicate with Attending Veterinarian (AV) and provide necessary animal health care

Learn technical/theoretical applications involved in executing pre-clinical studies Cell culture, inoculation, aseptic technique and contamination prevention

Proficiency monitoring tumor volume, body weight, clinical signs and model- dependent humane endpoints

Maintain clear and concise laboratory notes

Perform data quality control and upload relevant documents upon study completion

Work with IACUC to implement and ensure compliance of animal use protocols

Preferred functioning set of classical skills:

• Test article administration IV, IP, SC, IM, PO

• Perfusion

• Compound handling

• Tissue resection

• Biological sampling procedures

Execution of:

• Efficacy studies

• Biodistribution studies

• Pharmacokinetic studies

• Toxicokinetic studies

• Xenograft models

Mentor and train new staff

Work with radioactive and BSL2 samples and test articles

• Gamma counting

• Sample disposition

• Proper handling and disposal of associated materials

Communicate details of your work with scientists and managers

Provide husbandry support and routine health checks as needed

May assist under supervision in the operation of PET/SPECT/CT/MRI

Other duties as assigned

Highly Desired Skills

• Ability to perform minor surgical procedures
• Microdissection of tissues (lymph nodes, specific brain sections, etc)
• Experience working with anesthesia
• Experience working with radioactivity
• Experience working with BSL2 animals and samples
• Experience with IACUC/Animal Inventory management system (preferably Cayuse)
• Experience with PET/SPECT/MRI/BLI

Experience, Education, and Certifications

• Bachelor +5yrs experience OR MS +3yrs experience in Biology, Animal Science or a related field
• Ability to mentor junior staff
• Multitasking, organizational and time management skills
• Comfort with various computer operating systems and programs
• Strong written and oral communication skills
• Availability to work some weekends as required
• Ability to lift 50 pounds

This role is based in the Perceptive office/lab located in Needham, MA. The annual base salary range for this role is $52,520- $97,537. This range represents the anticipated initial annual salary and may vary depending on several factors including the candidate's experience and skills and may be subject to market rate adjustment.

Come as you are.

We're proud to be an Equal Employment Opportunity employer. We do not discriminate based upon race, religion, colour, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.