Senior Bioinformatics Engineer

BiomeSense

Chicago, IL

JOB DETAILS
JOB TYPE
Full-time
SKILLS
Algorithms, Amazon Web Services (AWS), Analysis Skills, Application Programming Interface (API), Artificial Intelligence (AI), Best Practices, Bioinformatics, Biology, Biotech and Pharmaceutical, Cloud Computing, Communication Skills, Computer Security, Data Sets, Distributed Computing, Documentation, ICD-11, Internet Technology, JavaScript, Medicine, Metadata, Ontology, PostgreSQL, Python Programming/Scripting Language, Quality Control, REST (Representational State Transfer), Relational Databases (RDBMS), SQL Databases, Software Engineering, Startup, Statistics, Training Data Sets, User Interface/Experience (UI/UX), Workflow Analysis
LOCATION
Chicago, IL
POSTED
30+ days ago
Senior Bioinformatics Engineer
Compensation: $125K – $200K base +  0.25% - 0.5% equity stock options

About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.

Position
Help build our MetaBiome platform, a software solution for collecting, curating & analyzing longitudinal GMB & health data at scale. Own the infra, pipelines & analytical workflows that turn raw sequencing data into intelligence, with room to grow into a platform leader.

Responsibilities:
  • Bioinformatics Architecture & Infrastructure - design, implement & maintain auditable backend for GMB data from raw shotgun metagenomic sequencing
  • Data Engineering build & maintain cloud infra: databases, distributed computing workflows & REST endpoints for microbial sequence & clinical metadata
  • Statistical Analysis – Lead design, execution & documentation of reproducible computational experiments end-to-end
  • Methods Development Develop & implement novel analytical methodologies & algorithms informed by experimental findings & validated via rigorous evaluation
  • Frontend / Backend Development Design & implement robust data ingestion interfaces leveraging APIs & clinical ontologies, following best practices

Qualifications
Required
  • B.S. /M.S. /PhD in Computational Biology, Bioinformatics or a related field with 3+ yrs industry experience (biotech start-up ideal)
  • Proficiency in Python & JavaScript & experience in production-quality software
  • PostgreSQL or other relational SQL database proficiency
  • Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC)
  • Familiarity with AWS & best practices in computer security
  • Proficiency with modern frontend web technologies
  • Excellent communication; translates complex scientific concepts to diverse stakeholders
  • Strong ownership mindset & the ability to execute in fast-moving environments
  • Expertise in bioinformatics pipelines, QC & reproducibility

Preferred
  • NGS data experience
  • Familiarity with longitudinal / repeated-measures biological datasets & GMB-specific challenges (compositional data, variability, confounders)
  • Experience integrating ontologies / standardized vocabularies
  • Exposure to cloud infrastructure, workflow orchestration or containerization
  • Interest in AI/ML for large biological datasets

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About the Company

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BiomeSense