Senior Manager, Benefits & HRIS

Role Overview & Key Functions:

SUMMARY:

The Senior Manager, Benefits & HRIS is responsible for leading and optimizing the company''s employee benefits programs, HRIS platforms, employee data governance, and related HR operational processes across the organization. This role serves as a trusted partner to leaders and employees, ensuring benefit program effectiveness, HRIS data integrity, compliance, and a seamless employee experience throughout the employee lifecycle. The Senior Manager will oversee benefits and HRIS programs, lead process improvement initiatives, and partner cross-functionally to support the company''s people strategy.

At Karyopharm, our HR team is a strategic partner to the business while creating a thoughtful, high-quality employee experience grounded in collaboration, responsiveness, data accuracy, and continuous improvement.

RESPONSIBILITIES:

Leads the strategy, administration, governance, and continuous improvement of Benefits, HRIS, and related HR operations in alignment with business objectives.

• Oversees health and welfare, retirement, leave, disability, wellness, and voluntary benefits programs, including plan design, renewals, benchmarking, open enrollment, and employee communications.

• Manages broker, carrier, retirement plan, COBRA, FSA/HSA, leave administration, HRIS, and other vendor relationships, including contracts, service levels, escalations, budgets, purchase orders, and compliance deliverables.

• Ensures compliance with applicable benefits and employment requirements, including ERISA, ACA, COBRA, HIPAA, Section 125, FMLA, ADA, required filings, notices, plan documents, Forms 5500, ACA reporting, nondiscrimination testing, audits, SOPs, and documentation retention.

• Provides guidance to employees and managers on benefits, leave administration, HR policies and procedures, HRIS, employee data, and HR operational best practices.

• Oversees HRIS data integrity, reporting, employee records, workflows, system security, access controls, confidentiality protocols, and audit readiness.

• Leads HRIS configuration, enhancements, integrations, testing, release management, and employee self-service tools to support scalable HR processes.

• Develops HR metrics and uses AI-enabled tools, people analytics, and workforce data insights to improve operational efficiency, automate processes, support workforce planning, and enhance the employee experience.

• Partners with Payroll, Finance, Accounting, IT, Legal, Quality, and external partners on benefits deductions, payroll integrations, budgeting, invoice reconciliation, accruals, cost analysis, and related operational needs.

• Supports onboarding, offboarding, Inclusion & Wellness initiatives, and related employee communications through accurate eligibility administration, HRIS updates, planning, and execution.

• Leads, coaches, and develops Benefits and HRIS team members while promoting collaboration, responsiveness, confidentiality, data accuracy, and continuous improvement.

Candidate Profile & Requirements:

REQUIREMENTS:

• Bachelor''s degree in Human Resources, Business Administration, Finance, Information Systems, or related field; Master''s degree or relevant certification preferred.

• 8+ years of HR experience, including 5+ years leading benefits, HRIS, or HR Operations programs.

• Strong knowledge of benefits administration and compliance, including ERISA, ACA, COBRA, HIPAA, FMLA, ADA, Section 125, and retirement plans.

• Experience leading open enrollment, plan renewals/design, vendor management, employee communications, and Benefits/HRIS projects.

• Proficiency with HRIS, benefits platforms, payroll integrations, reporting tools, Microsoft Office, and AI-enabled HR tools.

• Strong analytical, organizational, communication, and relationship-building skills with high attention to detail, confidentiality, and data accuracy.

• Ability to manage multiple priorities, budgets, vendors, process improvements, and cross-functional initiatives; biotech/pharma or regulated-industry experience preferred.

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $140 K - $175 K USD.

Our Value Proposition:

This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.

Our lead therapy, XPOVIO (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.

As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.

Learn more at Karyopharm Therapeutics.