Overview
Monte Rosa Therapeutics is seeking a passionate Senior Research Associate with the experience to implement and run biochemical and biophysical characterization assays. This is an exciting opportunity to join a team responsible for the characterization of novel small molecule glue-based degraders to support Monte Rosa's growing pipeline. The successful candidate will have proven bench level expertise in establishing and performing a range of biochemical and biophysical assays to screen and characterize small molecule compounds and elucidate mechanism of action. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional teams, as well as demonstrate a high degree of independence and organization.
Responsibilities
Design, develop and implement a variety of kinetic-focused, protein-protein interaction/degradation assays in low and high-throughput settings.
Standard assays include TR-FRET, FP, DSF, DLS, and SPR
Screen and characterize small molecule compounds and determine the mode of action.
Experience in handling and QCing recombinant protein
Standard assays include DSF/DLS, FIDA, and analytical SEC
Analyze and interpret integrated datasets.
Maintain laboratory records, protocols, and summaries.
Contribute to laboratory organization and maintenance.
Present research plans and results, both within the team and to senior management.
Qualifications